Nepomuceno-Silva, J.L. et al. (2004) RJLs: a new family of Ras-related GTP-binding proteins. Gene 327, 221-232Nepomuceno-Silva, J. L., L. D. de Melo, S. M. Mendonca, J. C. Paixao, and U. G. Lopes. 2004 . RJLs: a new family of Ras-related GTP-binding proteins. ...
The role of the Ras-related GTP-binding protein, Rab1B, in intracellular trafficking of β-amyloid precursor protein (βAPP) was studied in cultured 293 cells. βAPP is processed via one of two alternative routes. In the major secretory pathway,βAPP is cleaved by α-secretase within the ...
中文名称RAS相关GTP结合蛋白A抗体品牌 别名RRAGB; Adenovirus E3 14.7 kDa-interacting protein 1; FIP1; Rag A; RAg B; RagA; RAGB; Ras related GTP binding protein A; Ras-related GTP binding protein B; RRAGA_HUMAN. 浓度1mg/1ml 规格0.2ml/200μg ...
( 1998 ) Small GTP-binding proteins of the Rho- and Ras-subfamilies are not involved in the actin rearrangements induced by attaching and effacing Escherichia coli . FEMS Microbiol Lett 163 : 107 – 112 .Ebel F, von Eichel-Streiber C, Rohde M, Chakraborty T. 1998. Small GTP-binding ...
A key aspect of this challenge is the fact that direct inhibition of RAS proteins has proved difficult, leading researchers to test numerous alternative strategies aimed at exploiting RAS-related vulnerabilities or targeting RAS effectors. In the past few years, we have witnessed renewed efforts to ...
30Citations 12Altmetric Metrics Abstract R-Ras2 is a transforming GTPase that shares downstream effectors with Ras subfamily proteins. However, little information exists about the function of this protein in tumorigenesis and its signalling overlap with classical Ras GTPases. Here we show, by combini...
产品介绍The protein encoded by this gene is a member of the RAS superfamily which are small GTP/GDP-binding proteins with an average size of 200 amino acids. The RAS-related proteins of the RAB/YPT family may play a role in the transport of proteins from the endoplasmic reticulum to the ...
(prenylation) of proteins, including the GTP-binding protein Ras, with farnesyl or geranylgeranyl isoprenoid groups, Clodronate did not inhibit protein prenylation, Mevastatin, an inhibitor of 3-hydroxy-3-methylglutatyl (HMG)-CoA reductase and hence the biosynthetic pathway required for the production...
This selection of alternative binding partners for oncogenic Ras-proteins can thus serve as a source for more in depth investigations of particular Ras-related phenomena. The following chapter will scrutinize these molecules with respect to their functions and biochemical properties...
Ras is a membrane-associated small G-protein that funnels growth and differentiation signals into downstream signal transduction pathways by cycling between an inactive, GDP-bound and an active, GTP-bound state. Aberrant Ras activity as a result of oncog