Ly-GDI, a GDP-dissociation inhibitor of the RhoA GTP-binding protein, is expressed preferentially in lymphocytes The Ras-related small GTP-binding proteins are involved in diverse cellular events, including cell signaling, proliferation, cytoskeletal organization, and... P Scherle,BLM Staudt - 《Proc...
The regulatory function of the Ras-like GTPases in diverse cellular processes, such as growth, cell movement, and protein trafficking, is critically depend... MC Seabra - 《Cellular Signalling》 被引量: 441发表: 1998年 Measurement of GTP-bound Ras-like GTPases by activation-specific probes....
英文名字 Rac1 (Ras-related C3 Botulinum Toxin Substrate 1, Rho Family, Small GTP Binding Protein Rac1, Cell Migration-inducing gEne 5 Protein, MGC111543, MIG5, p21-Rac1, Ras-like Protein TC25)供应商 MyBioSource产品货号 MBS631427产品报价 ￥询价/0.05mg ￥询价/5x0.05mg ￥询价/其它规格产品...
to RasGEFs 36 , and later as a protein which inter- � acts with the GTP-bound form of Ras and several . other Ras-like GTPases, see below in yeast two w x hybrid screens 37,38 . Two distant relatives with w x similar structural and binding properties, Rgl 39 and w x Rlf 40...
In general, the GTP-bound form is the active form of the protein, and measurements of the ratio of GDP-GTP bound determines the activation state. Until recently the common method to measure the active GTP-bound form of small GTPases was immunoprecipitation of 32P- labeled protein followed by...
Binding was specific for guanine nucleotides and displayed unique magnesium dependence such that both GTP and GDP binding were optimal at relatively high Mg2+ concentrations (1-10 mM). Rad had low intrinsic GTPase activity which was greatly enhanced by a GTPase-activating protein (GAP) activity ...
Aravind L,Neuwald AF,Ponting CP.Sec14p-like domain in NF1 and Dbl-like proteins indicate lipid regulation of Ras and Rho Signaling. Current Biology . 2000Aravind L, Neuwald AF, Ponting CP: Sec14p-like domains in NF1 and Dbl-like proteins indicate lipid regulation of Ras and Rho ...
Ras guanine nucleotide-releasing protein (RasGRP) is one type of GEF (GTP/GDP exchange factor) responsible for the activation of Ras and/or Rap14,15. Each protein contains a Ras exchange motif to interact with Ras and/or Rap, CDC25, EF hands for Ca2 þ binding and C1 domain for ...
Small GTP-binding proteins of the Rab and Arf (ADP-ribosylation factor) families play a central role in the membrane trafficking pathways of eukaryotic cells. The prototypical members of the Arf family are Arf1-Arf6 and Sar1, which have ... S Munro - 《Biochemical Society Transactions》 被...
The regulatory function of the Ras-like GTPases in diverse cellular processes, such as growth, cell movement, and protein trafficking, is critically depend... MC Seabra - 《Cellular Signalling》 被引量: 441发表: 1998年 Measurement of GTP-bound Ras-like GTPases by activation-specific probes....