本文利用小鼠基因敲除、EAE模型、离体细胞定向分化和转录组测序等技术手段开展研究,结果表明GAP1家族成员Ras p21 protein activator 3 (RASA3)是pTh17产生所必需的;RASA3通过促进IRF4与E3泛素连接酶Cbl-b结合使得IRF4发生泛素化降解,减少IL-4表达,抑制Th2细胞分化,进而促进pTh17细胞分化。因此,RASA3-IRF4-Cbl-b...
We found that Ras p21 protein activator 3 (RASA3), a GTPase activating protein, was highly expressed by IL-1尾/IL-6/IL-23 induced-pTh17 cells relative to TGF尾1/IL-6 induced-non-pTh17 cells and was required specifically for pTh17 generation in vitro and in vivo. Mice conditionally ...
activating protein III; Inositol 1 3 4 5 tetrakisphosphate binding protein; Inositol 1345 tetrakisphosphate binding protein; Ins P4 binding protein; Ins(1 3 4 5)P4 binding protein; Ins(1345)P4 binding protein; Ras GTPase activating protein 3; RAS p21 protein activator 3; RASA 3.RASA3_HUMAN...
TC-25; p21-Rac1; MIG5; Cell migration-inducing gene 5 protein; Ras-like protein TC25; p21-Rac1来源:原核表达宿主:E.coli内毒素水平:<1.0EU/µg(LAL法测定)亚细胞定位:细胞膜, 细胞质预测分子量:24.8kDa实际分子量:25kDa(差异分析请参阅说明书)片段...
基因名全称RAS p21 protein activator (GTPase activating protein) 1 蛋白名全称Ras GTPase-activating protein 1 推荐稀释比 Western blot(WB) 1:500～2000 Immunocytochemistry/Immunofluorescence (ICC/IF) 1:50～400 Flow cytometry (FCM) 1～3μg/1×106cells...
1～3天 产品价格: 询价 本产品仅可用于科研实验,严禁用于其他非科研用途! 抗体名称Anti-RASGAP/RASA1 Antibody 指标别名CM AVM;CMAVM;GAP;GTPase activating protein;p120GAP;p120RASGAP;PKWS;Ras p21 protein activator;RASA;RASA1;RASGAP 克隆性Polyclonal ...
9. Bonfini, L., Karlovich, C. A., Dasgupta, C. & Banerjee, U. The Son of sevenless geneproduct: a putative activator of Ras. Science 255, 603–606 (1992). 10. Buday, L. D. J. Epidermal growth factor regulates p21 ras through the formatio...
activating protein III; Inositol 1 3 4 5 tetrakisphosphate binding protein; Inositol 1345 tetrakisphosphate binding protein; Ins P4 binding protein; Ins(1 3 4 5)P4 binding protein; Ins(1345)P4 binding protein; Ras GTPase activating protein 3; RAS p21 protein activator 3; RASA 3.RASA3_HUMAN...
蛋白别名: c-H-ras; c-has/bas p21 protein; c-ras-Ki-2 activated oncogene; GTP- and GDP-binding peptide B; GTPase HRas; GTPase Hras1; H-Ras-1; Ha-Ras; Ha-Ras1 proto-oncoprotein; Harvey rat sarcoma viral oncogene homolog; Harvey rat sarcoma viral oncoprotein; p19 H-RasIDX protein;...
别名:Oncogene RRAS; p23; R Ras; Ras related Protein; Ras related protein R Ras; Ras-related protein R-Ras; related RAS viral (r ras) oncogene homolog; RRAS; RRAS_HUMAN. 研究领域:肿瘤细胞生物 信号转导 细胞凋亡 转录调节因子 G蛋白信号 ...