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The Ras GTPase-activating-like protein IQGAP1 is associated to the slit diaphragm proteins and the actin cytoskeleton in podocyte. Here, we studied IQGAP1 expression alterations in human DN biopsies and extracellular signal-regulated kinase (ERK)-dependent pathways of IQGAP1 expression in podocyte ...
别名:IQ motif containing GTPase activating protein 3; IQGA3_HUMAN; IQGAP 3 ; IQGAP3; MGC10170; MGC10831; MGC1947 antibodyOTTHUMP00000031854 ; OTTHUMP00000031855; Ras GTPase activating like protein IQGAP3; Ras GTPase-activating-like protein IQGAP3. ...
(Ras protein activator like 2,RASAL2)、GTPase活化蛋白1(GTPase-activating protein 1,RASA1)、IQ 样GTPase活化蛋白同源体1(IQ motif containing GTPase-activating protein homologue 1,IQGAP1)、IQGAP2等,其共同特点是都含有1个与Ras蛋白结合区域——RasGAP区,行使与Ras蛋白结合后的催化功能,发挥调节RAS通路的...
RAS—GTPase活化蛋白(RAS—GAPs)是一类肿瘤抑制性基因,可通过与活化的RAS—GTPase结合,水解GTP,使活化的Ras蛋白转化为非活化状态,从而抑制下游分子通路激活,抑制肿瘤的发生与发展。当基因突变、启动子甲基化等原因使其功能失活后可致Ras蛋白处于持续活化状态,促进肿瘤的发生、发展。本文总结了近年来RASGAPs在肿瘤中的...
(GTPase Activating Protein). AKT-dependent TSC2 phosphorylation releases TSC1/2 inhibition by the GTPase RHEB (RAS homolog abundant in brain), ultimately activating mTORC1, which regulates cell growth. Both the RAS/RAF/MAPK and PI3K/AKT/mTOR pathways frequently experience dysregulation in many ...
Rap2a,andRap2b,twoR-ras-likeproteins,R-rasandTC21,twoRalproteins,RalAandRalB,andtherecentlyidentifiedRhebprotein.Animportantcharacteristicofthisfamilyis�.theirsimilarityintheeffectordomainFig.1.Thisregion,alsocalledtheswitchoneregion,undergoesadramaticconformationalchangeduringtheconver-sionoftheGDP-boundform...
The IQ-motif containing Ras GTPase-activating-like protein (IQGAP) family of proteins consists of 3 members in mammals, termed IQGAP1, IQGAP2, and IQGAP35. IQGAPs function as scaffolds for various signaling pathways and modulate diverse biological processes6. IQGAP1 is the most well studied...
主要包括:神经纤维素1(neurofibrom in 1,NF1)、DAB2相互作用蛋白(DAB2-interacting protein,DAB2IP)、Ras p21蛋白活化子1(RAS p21 protein activator 1,RASA1)、Ras GTP酶激活因子(Ras-GTPase-activating-like protein,RASAL)和IQ结构的GTP酶活化蛋白2(IQ-motif-containing GTPase activating protein2,IQGAP2)...
产品别名: IQ motif containing GTPase activating protein 3; IQGA3_HUMAN; IQGAP 3 ; IQGAP3; MGC10170; MGC10831; MGC1947 antibodyOTTHUMP00000031854 ; OTTHUMP00000031855; Ras GTPase activating like protein IQGAP3; Ras GTPase-activating-like protein IQGAP3. ...