The Ras GTPase-activating-like protein IQGAP1 is associated to the slit diaphragm proteins and the actin cytoskeleton in podocyte. Here, we studied IQGAP1 expression alterations in human DN biopsies and extracellular signal-regulated kinase (ERK)-dependent pathways of IQGAP1 expression in podocyte ...
Amino acid sequence analysis identified the protein as IQGAP1, a recently described human Ras GTPase-activating-like protein suspected to act as an effector molecule for Cdc42 and Rac1, members of the Rho small GTPase family and to play a key part in regulating E-cadherin-mediated cell ...
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The IQ-motif containing Ras GTPase-activating-like protein (IQGAP) family of proteins consists of 3 members in mammals, termed IQGAP1, IQGAP2, and IQGAP35. IQGAPs function as scaffolds for various signaling pathways and modulate diverse biological processes6. IQGAP1 is the most well studied...
中文名称RasGTP酶激活蛋白IQGAP3抗体 别名IQ motif containing GTPase activating protein 3; IQGA3_HUMAN; IQGAP 3 ; IQGAP3; MGC10170; MGC10831; MGC1947 antibodyOTTHUMP00000031854 ; OTTHUMP00000031855; Ras GTPase activating like protein IQGAP3; Ras GTPase-activating-like protein IQGAP3. ...
产品别名: IQ motif containing GTPase activating protein 3; IQGA3_HUMAN; IQGAP 3 ; IQGAP3; MGC10170; MGC10831; MGC1947 antibodyOTTHUMP00000031854 ; OTTHUMP00000031855; Ras GTPase activating like protein IQGAP3; Ras GTPase-activating-like protein IQGAP3. ...
关键词:RAS—GTPase活化蛋白;肿瘤中图分类号:R1文献标志码:A文章编号:1000—503X(2015)03—0364—06D0I:10.3881/j.issn.1000—503X.2015.03.024ResearchAdvancesintheRoleofRAS-GTPase-activatingProteinsinTumorsZHANGHong—kai,CHENJieDepartmentofPathology,PUMCHospital,CAMSandPUMC,Beijing100730,ChinaCorresponding...
Rap1b,Rap2a,andRap2b,twoR-ras-likeproteins,R-rasandTC21,twoRalproteins,RalAandRalB,andtherecentlyidentifiedRhebprotein.Animportantcharacteristicofthisfamilyis�.theirsimilarityintheeffectordomainFig.1.Thisregion,alsocalledtheswitchoneregion,undergoesadramaticconformationalchangeduringtheconver-sionoftheGDP-...
(GTPase Activating Protein). AKT-dependent TSC2 phosphorylation releases TSC1/2 inhibition by the GTPase RHEB (RAS homolog abundant in brain), ultimately activating mTORC1, which regulates cell growth. Both the RAS/RAF/MAPK and PI3K/AKT/mTOR pathways frequently experience dysregulation in many ...
(Ras protein activator like 2,RASAL2)、GTPase活化蛋白1(GTPase-activating protein 1,RASA1)、IQ 样GTPase活化蛋白同源体1(IQ motif containing GTPase-activating protein homologue 1,IQGAP1)、IQGAP2等,其共同特点是都含有1个与Ras蛋白结合区域——RasGAP区,行使与Ras蛋白结合后的催化功能,发挥调节RAS通路的...