RAS蛋白作为酪氨酸激酶的下游信号通路蛋白,可被鸟嘌呤核苷酸交换因子(Guanine nucleotide exchange factors, GEFs)如SOS1蛋白调控,而GTP酶激活蛋白(GTPase activating proteins, GAPs)可负向调控RAS蛋白。RAS-GDP为非激活状态,RAS-GTP为激活...
Ras GTPase-activating protein (GAP), an important downregulator of Ras activity, has previously been shown to be abundant in human placenta. The expression of p120 and p100 isoforms of GAP in human normal chorionic villi (n=5) and hydatidiform mole (n=5) was investigated to clarify the ...
GTPase GDP二磷酸鸟苷 GAP:GTP酶激活蛋白。Ras蛋白结合GTP时活化并具有GTPase活性,以水解结合在自身上的GTP为GDP,恢复至无活性状态 ,GTP酶活性受GTP酶激活蛋白(GTPase activating protein,GAP)控制 MAPK:(丝裂原活化蛋白激酶,mitogen-activated protein kinase)一组能被不同的细胞外刺激,如细胞因子 、 神经递质 、...
与内在速率相比,GAP是RAS的GTPase活性增加了五倍。 -因此,在细胞内RAS-bound GTP的正常水解依赖于GAP,比如neurofibromin (NF1) or Ras GTPase-activating protein 1 (RASA1; also known as p120RASGAP),他们包含SH2/SH3结构与或其他结合motifs,因此也被招募到激活的RTKs和scaffolding adapters中,作为关闭RAS信号...
别名GAP1M; GTPase activating protein of RAS; Ras GTPase activating protein 2; Ras GTPase-activating protein 2; RAS p21 protein activator 2; RASA2; RASA2_HUMAN; RASGAP. 研究领域细胞生物染色质和核信号细胞周期蛋白细胞分化 蛋白分子量predicted molecular weight: 96kDa ...
别 名;GAP1M; GTPase activating protein of RAS; Ras GTPase activating protein 2; Ras GTPase-activating protein 2; RAS p21 protein activator 2; RASA2; RASA2_HUMAN; RASGAP. 第一抗体就是平常所说的抗体,即能和抗原特异性结合。 第二抗体是能和抗体结合的,即抗体的抗体。主要用于检测抗体的存在。 一...
(Ras protein activator like 2,RASAL2)、GTPase活化蛋白1(GTPase-activating protein 1,RASA1)、IQ 样GTPase活化蛋白同源体1(IQ motif containing GTPase-activating protein homologue 1,IQGAP1)、IQGAP2等,其共同特点是都含有1个与Ras蛋白结合区域——RasGAP区,行使与Ras蛋白结合后的催化功能,发挥调节RAS通路的...
文档标签: P120-Ras GTPase activating protein 40RasGAP41 A multi-interacting in downstream signaling 系统标签: rasgap gtpase ras activating signaling protein ReviewP120-RasGTPaseactivatingprotein(RasGAP):Amulti-interactingproteinindownstreamsignalingPerayotPamonsinlapathama,b,1,2,Re´daHadj-Slimanea,...
GAPGTPase-activating proteinGEFguanine nucleotide exchange factorAberrant activation of the RAS pathway is ubiquitous in human hepatocarcinogenesis, but the molecular mechanisms leading to RAS induction in the absence of RAS mutations remain under-investigated. We defined the role of Ras GTPase activating ...
Escobar-Hoyos团队等在Cancer Cell上发表了文章,首次报道了PDAC中突变型K-Ras与p53蛋白之间存在的依赖于GTP酶激活蛋白(GTPase-activating protein, GAP)的异常剪接和膜定位的协同促癌机制,为携带KRASG12D突变体的胰腺癌患者的治疗提供了一项新的潜在有效方案。这一研究通过大量的体外与体内实验数据,验证了在PDAC中,...