文章标题:He-Chan Pian inhibits the metastasis of non-small cell lung cancer via the miR-205-5p-mediated regulation of the GREM1/Rap1 signaling pathway 发表期刊:Phytomedicine 发表时间:2021.10.24 …
Rap1 signaling pathway Rap1 is a small GTPase that controls diverse processes, such as cell adhesion, cell-cell junction formation and cell polarity. Like all G proteins, Rap1 cycles between an inactive GDP-bound and an active GTP-bound conformation. A variety of extracellular signals control ...
Recent studies have found that Epac鄄Rap1 signaling pathway,which activates downstream signaling cas- cade systems,plays a significant role in the pathophysiology of diabetic nephropathy by promoting cell hypertro- phy,mediating renal interstitial fibrosis and up鄄regulating the expression of inflammatory ...
Rap1 信号通路表明,GREM1表达受 miR-205-5p 调节(图3E)。因此,HCP通过调节Rap1信号通路发挥抗肿瘤作用,GREM1是NSCLC转移的重要治疗靶点。 图3 HCP可抑制EMT、GREM1表达及相关通路(A)(B)为蛋白水平结果,(C)(D)为层次聚类热力图,(E)为通路图 GREM1通过调节EMT和Rap1通路促进转移 使用CCK-8测定评估GREM1对...
miR-204通过RAP1信号通路诱导多形性胶质母细胞瘤凋亡[J]. 实用药物与临床, 2017, 20(2):132-136. Wang HC, Zhao H. miRNA-204 induces apoptosis of glioblastoma multiforme by RAP1 signaling pathway[J]. Prac Pharm Clin ...
Functions for the cAMP/Epac/Rap1 signaling pathway in low-dose endothelial monocyteactivating polypeptide-II-induced opening of blood-tumor barrier. Li Z,Liu XB,Liu YH,et al. Journal of Molecular Neuroscience . 2015Li Z., Liu X. B., Liu Y. H., Xue Y. X., Wang P., Liu L. B.,...
The Epac-1/Rap-1 hub modulated the JAK-2/STAT-3/SOCS-3 signaling pathway and stimulated the PI3K/AKT signal to activate Nrf-2/HO-1 axis. The crosstalk between these pathways explains partly the renotherapeutic potential of ticagrelor via augmenting its anti-inflammatory/-oxidant and -apoptotic...
CONCLUSION Our study reveal that Epac1/Rap1 signaling pathway is involved in the pathogenesis of myocardial I/R injury in rats,which provides evidence on the development of therapeutic strategies target this pathway for myocardial I/R injury. 展开 关键词: 急性心肌缺血;冠状动脉;治疗方法;临床分析...
Hence, the current study aimed to investigate the possible therapeutic effectiveness of ticagrelor, against renal ischemia/reperfusion (I/R) model with emphasis on the involvement of Epac-1 signaling pathway using R-CE3F4, a selective Epac-1 blocker. Accordingly, rats were randomized into four ...
Functions for the cAMP/Epac/Rap1 signaling pathway in low-dose endothelial monocyteactivating polypeptide-II-induced opening of blood-tumor barrier. Li Z,... Liu,Li-bo,Yun-hui,... - 《Journal of Molecular Neuroscience Mn》 被引量: 5发表: 2015年 Functions for the cAMP/Epac/Rap1 Signaling...