因此,这些结果表明GREM1在Rap1通路的调节中起重要作用,并可能通过激活该通路促进NSCLC的转移。 图4 OE-GREM1通过Rap1途径调节EMT进展,促进A549细胞转移 图5 ShGREM1通过Rap1通路调节EMT进展来影响A549细胞的转移 GREM1不促进A549异种移植小鼠模型的增殖 为了检查GREM1在体内A549细胞生长中的作用,作者使用裸鼠进行异种...
Recent studies have found that Epac鄄Rap1 signaling pathway,which activates downstream signaling cas- cade systems,plays a significant role in the pathophysiology of diabetic nephropathy by promoting cell hypertro- phy,mediating renal interstitial fibrosis and up鄄regulating the expression of inflammatory ...
miRNA-204 induces apoptosis of glioblastoma multiforme by RAP1 signaling pathway[J]. Prac Pharm Clin Rem, 2017, 20(2):132-136. 22. Schmid MC, Franco I, Kang SW, et al. PI3-kinase γ promotes Rap1a-mediated ac...
The mechanism may be through the Epac - Rapl signaling pathway to regulate myocardial ischemia-reperfusion injury in rats. Keywords: Signaling Pathways / Myocardial Ischemia / Reperfusion Injury Epac-Rap1信号通路在大鼠心肌缺血灌注再损伤中的 调控作用及相关机制研究 1前言冠心病是冠状动脉粥样硬化性心脏病...
[26IKimJH,KimSJ,LeeIS,eta1Bacterialendotoxininduces血ereleaseofhighmobilitygroupbox1viatheIFN—Bsignalingpath-waylJ.JImmunol,2009,182(22):2458-2466.收稿日期:2010—10—12修回日期:2010—12—13SPA-1通过Rapl信号通路参与疾病的发生和发展李敏(综述),冯爱平,苏莉(审校)(1.华中科技大学同济医学院附属协和...
The Epac-Rap1 signaling pathway controls cAMP-mediated exocytosis of Weibel-Palade bodies in endothelial cells. Endothelial cells contain specialized storage organelles called Weibel-Palade bodies (WPBs) that release their content into the vascular lumen in response ... KWEM Van Hooren,EL Van Agtmaa...
quercetin is through the cAMP-Epac-Rap1 pathway in the acute lung injury and its possible mechanism. Results of the study will illustrate the new target significance of the Epac-Rap1 signaling pathway in the prevention of ALI, and elucidate the molecular mechanism of treatment of quercetin in ...
[35] Liang Y, Zhou R, Fu X, et al. HOXA5 counteracts the function of pathological scar-derived fibroblasts by partially activating p53 signaling. Cell Death Dis. 2021;12(1):40. [36] Huang HP, Liu WJ, Guo QL, et al. Effect of silencing HOXA5 gene expression using RNA interference ...
进一步的Pathway Crosstalk分析发现BL02主要调节参与EGFR信号传导(ErbB受体、EGFR依赖性通路)和细胞粘附通路(Cdc42信号传导和细胞β3整合素相互作用)的基因(图4d)。NSCLC是一种恶性肿瘤,通常含有EGFR突变,因此目前针对EGFR的酪氨酸激酶抑制剂...