quercetin is through the cAMP-Epac-Rap1 pathway in the acute lung injury and its possible mechanism. Results of the study will illustrate the new target significance of the Epac-Rap1 signaling pathway in the prevention of ALI, and elucidate the molecular mechanism of treatment of quercetin in ...
CONCLUSION Our study reveal that Epac1/Rap1 signaling pathway is involved in the pathogenesis of myocardial I/R injury in rats,which provides evidence on the development of therapeutic strategies target this pathway for myocardial I/R injury. 展开 关键词: 急性心肌缺血;冠状动脉;治疗方法;临床分析...
For five patients, a polymorphism in Epac at codon 332 (Gly--Ser) was observed.In this report, we show that the cAMP--Epac--Rap1 signaling pathway in the thyroid gland does not play a major role in the generation of cold thyroid follicular adenomas, since no mutations in either Epac ...
Rap1 signaling pathway Rap1 is a small GTPase that controls diverse processes, such as cell adhesion, cell-cell junction formation and cell polarity. Like all G proteins, Rap1 cycles between an inactive GDP-bound and an active GTP-bound conformation. A variety of extracellular signals control ...
Rap1GAP Apoptosis Inflammation Oxidative stress Myocardial infarction AMPK/SIRT1/NF-κB signaling pathway 1. Introduction Acute myocardial infarction (AMI) is a disease with a very high incidence and mortality worldwide. Approximately 7 million people suffer from this disease each year, and it causes...
Therefore, our results demonstrate PRL-3 as a novel regulator of NF-κB signaling pathway through RAP1. Highlights ► PRL-3 interacts with telomere-related protein RAP1. ► PRL-3 promotes cytosolic localization of RAP1. ► RAP1 contributes to PRL-3-regulated gene expression and ...
et al. Histone deacetylase inhibitor FK228 suppresses the Ras–MAP kinase signaling pathway by upregulating Rap1 and induces apoptosis in malignant melanoma. Oncogene 25, 512–524 (2006). https://doi.org/10.1038/sj.onc.1209072 Download citation Received04 March 2005 Revised26 July 2005 Accepted29...
Objective:The cyclic AMP (cAMP) cascade is the main regulatory pathway in thyrocytes. Whilst activating mutations in the TSH receptor or in the Gs alpha-subunit, which increase cAMP levels, have been shown to be responsible for 80% of the autonomous adenomas, no such mutations have been observ...
Hence, the current study aimed to investigate the possible therapeutic effectiveness of ticagrelor, against renal ischemia/reperfusion (I/R) model with emphasis on the involvement of Epac-1 signaling pathway using R-CE3F4, a selective Epac-1 blocker. Accordingly, rats were randomized into four ...
However, it is unknown whether the EPAC-Rap1 signaling pathway regulates the tight junctions (TJs) of retinal endothelial cells and the relationship between EPAC-Rap1 and VEGF signaling in retinal permeability is poorly understood. The goals of this thesis are to: 1) determine whether EPAC-Rap1...