This proved to be receptor activator of NF-kB ligand (RANKL) a member of the tumor necrosis factor ligand family that acts upon its receptor RANK in the hematopoietic lineage, with interaction restricted by a decoy soluble receptor osteoprotegerin (OPG), also a product of the osteoblast lineage...
Role of RANKL/RANK/OPG axis on bone homeostasis and immune system. RANKL is secreted by osteoblasts and osteocytes when stimulated by parathyroid hormone (PTH), vitamin D, and/or prostaglandin 2 (PGE2). RANKL binds to RA...
The RANKL/RANK/OPG system was first identified in the late-1990s as a pivotal regulator of bone remodeling [1,2,3]. It consists of three main signaling molecules: the cytokine receptor activator of nuclear factor (NF)-kB-ligand (RANKL; see Table1for the list of abbreviations), the recepto...
inflammatory reactions, bone destruction, and joint dysfunction, play the key role in the pathogenesis of RA. This article reviews the relevant research on the intervention of RA through the regulation of osteoprotegerin
The biologic mechanisms involved in the pathogenesis of multiple myeloma (MM) bone disease are not completely understood. Recent evidence suggests that T cells may regulate bone resorption through the cross-talk between the critical osteoclastogenetic factor, receptor activator of nuclear factor-κB ...
3.Insulin induced ERK 1/2 and Akt signal pathway in rat CVSMCs.4.The cffect that insulin increased CVSMCs RANKL mRNA was blocked by pretreatment of CVSMCs with ERK inhibitor.That data suggested that ERK played an important role in increasing the expression of RANKL in rat CVSMCs. ...
Activation of both the AP-1 and NF-κB pathways is instrumental in promoting osteoclast survival, underscoring their significance in bone physiology. Consequently, targeting these pathways holds promise as a potential therapeutic strategy for addressing bone disorders characterized by excessive bone resorptio...
Kong et al., “Osteoprotegerin ligand: a regulator of immune responses and bone physiology,” Immun. Today, 21(10): 495-502 (2000). Kostenuik et al., “OPG and PTH-(1-34) have addictive effects on bone density and mechanical strength in osteopenic ovariectomized rats,” Endocrin., 14...
Over the past decades, it has become clear that the RANK-RANKL axis is not exclusively involved in bone remodelling [9], but exerts a broad range of functions in the body. The RANK-RANKL axis is known to play an important role in the immune system [10], mammary physiology, mammary tumo...
RANKL/OPG; Critical role in bone physiology Article 04 January 2015 Recent advances in osteoclast biology Article 01 February 2018 Introduction Bone serves multiple functions in vertebrates, including support for muscles, protection of vital organs and hematopoietic marrow, and storage and release of...