Sclerotic Bone Metastasis in Pulmonary Adenocarcinoma Bacterial lipopolysaccharides and RANKL induce human peripheral blood mononuclear cells to express A20, which is associated with TRAF6 and NF-kB degradation. Deubiquitinating Enzymes and Bone Remodeling RANKL and OPG are members of the superfamily of tumo...
Denosumab, a monoclonal antibody targeting receptor activator of nuclear factor kappa-B ligand (RANKL), was found to be a promising new therapeutic strategy for patients with bone metastases by restricting bone destruction. However, the scientific community should be aware of the possible association ...
You’re a woman.Osteoporosis does occur in men but it’s far more common in women. Roughly 80% of the 10 million people with osteoporosis are females, and the risk of women breaking a bone is greater than that of heart attack, stroke, and breast cancer combined, according to the Bone ...
You’re a woman.Osteoporosis does occur in men but it’s far more common in women. Roughly 80% of the 10 million people with osteoporosis are females, and the risk of women breaking a bone is greater than that of heart attack, stroke, and breast cancer combined, according to the Bone ...
Denosumab offers a new choice for the treatment of postmenopausal osteoporosis in patients at high risk for fracture. 展开 关键词: Denosumab RANKL Postmenopausal osteoporosis Osteoporosis treatment Bone mass Vertebral fractures DOI: 10.1007/s11914-010-0040-1 被引量: 7 ...
The combination of intermediate doses of thalidomide with dexamethasone is an effective treatment for patients with refractory/relapsed multiple myeloma and normalizes abnormal bone remodeling, through the reduction of sRANKL/osteoprotegerin ratio. Leukemia. 2005;19(11):1969–76. https://doi.org/...
Descending interneurones of the locust reporting deviation from flight course: what is their role in steering? J Exp Biol. 1989; 146 :177–194... CHF Rowell - 《Journal of Experimental Biology》 被引量: 0发表: 1989年 The control of sets of motoneurones by local interneurones in the locust...
A dual energy X-ray absorptiometry (DEXA or DXA) scan can be used as a screening test for osteopenia (bone loss that precedes osteoporosis). This test measures bone density in the hip and spine and is more precise than an X-ray.
ycle is key to therapeutic development. Metastic Breast Tumor Cell PTHrP VEGF IL-6 IL-8 IL-11 Others RANKL OPG Growth Survival VEGF IL-6 IL-8 IL-11 Others IGF-1 TGF-β Ca2+ Others Activation Differentiation Pre-Osteoclasts Osteoblasts Osteoclast Figure 1. The vicious cycle of breast ...
3.9. Osteoclast Formation and Bone Erosion In addition to their inflammatory role, monocytes and macrophages contribute to the formation of osteoclasts, cells responsible for bone resorption. Under the influence of cytokines such as RANKL, produced by activated T cells and SFs, monocytes differentiate ...