RANK ligand (RANKL), a member of the tumor necrosis factor (TNF) cytokine family, is required for differentiation, activation, and survival of osteoclasts and thus plays a critical role in cancer-induced bone disease. Under normal circumstances, RANKL activity is attenuated by its endogenous ...
Receptor activator of NF-魏B ligand (RANKL) is a multifunctional cytokine known to affect immune and skeletal systems, as well as oncogenesis and metastasis. RANKL is synthesized as a membrane-bound molecule, and cleaved into its soluble form by proteases. As the soluble form of RANKL does ...
RANKL Induces IL-18 Binding Protein Expression in RAW264.7 Cells The receptor activator of NF-魏B (RANK) ligand (RANKL) is a cytokine that is essential for osteoclast development, whereas interleukin (IL)-18 suppresses o... Y Takahashi,H Tanaka,K Nakai,... - 《Journal of Hard Tissue Biol...
We also found that serum levels of receptor activator of nuclear factor kappa B ligand (RANKL), a cytokine essential for osteoclastogenesis41, increased inEnpp1ttw/ttwmice fed a HPD compared withEnpp1ttw/ttwmice fed a ND or WT mice fed either diet (Supplementary Fig.3a), but serum osteopr...
Fewer TRAP-positive mature osteoclasts were found in KO BM cell cultures.Our data show that the active involvement of properdin in arthritis is related to an increased proinflammatory cytokine production and RANKL expression on immune cells and to a stimulation of the RANKL-dependent osteoclast ...
C, splenic hematopoietic progenitors from the RANK−/− mouse were infected with each of the hRANK retroviral constructs and a control retrovirus encoding lacZ. Cells were then cultured for 5 days with CSF-1 in the presence of RANKL. Indirect immunofluorescence was used to reveal the human ...
JNK activation is required for apoptosis but c-jun, a protein in the JNK signaling pathway, is not always required. Search New understanding of fresh brominated relationship retardants (NBFRs): Neuro(endocrine) accumulation Posted onNovember 30, 2024 ...
A Evaluation of cytokine levels in the serum of MM-inoculated (pooled from 3 mice) and non-injected control (pooled from 3 mice) animals using cytokine array. B Levels of mCXCL13 in the BM of MM-inoculated (n = 6) and control mice (n = 3), evaluated by qRT-PCR. Data...
It is also conceivable that Epo may promote the production of other OB- or OC-stimulating proteins such as Wnt proteins or RANKL. Increased levels of circulating Epo and decreased sensitivity of erythroid progenitors to this factor have been found in TfR2 − / − mice, used as a model ...
We first showed that exposure of T cells to levels of HIV envelope glycoprotein gp120 present in plasmas of HIV+ treatment-naive patients induced production of the primary cytokine for OC differentiation, receptor activator of nuclear factor κB ligand (RANKL). Supernatants from gp120-activated T ...