The role of OPG/RANKL/RANK signaling pathway in the pathogenesis of giant-cell tumor of bone Liang Chenliang1, Zhao Zhenqun2, Liu Wanlin2 PDF 142 摘要/Abstract 摘要: 文题释义: OPG/RANKL/RANK 信号通路:是骨代谢中至关重要的一条信号通路,它是成骨细胞与破骨细胞之间相互作用的信号通道,同时也是...
Furthermore, EGCG prevented degranulation of mast cell in RANKL-stimulated HMC-1 cells. Overall, these results suggest that EGCG acts as a natural agent for preventing and treating RANKL-mediated inflammatory diseases by targeting PI3 Kinase, MAP Kinase, caspase-1, and NF-κB signaling cascade in...
导致 B 细胞数量显着减少 (47, 49);然而,这些影响可能是间接的,因为在小鼠中,B 细胞中 Rank 的组织特异性缺失【 tissue-specific deletion 】显示出 B 细胞的功能和发育没有差异,并且用Denosumab阻断 RANK/RANKL 不会明显影响骨质疏松...
RANK-RANKL signaling pathway is critically involved in the function of CD4[+]CD25[+] regulatory T cells Kanai T, Nemoto Y et al (2009) RANK-RANKL signaling pathway is critically involved in the function of CD4+CD25+ regulatory T cells in chronic colitis... 戸塚,輝治,渡辺,守 - 《Clinica...
关键词:核因子 κB 受体活化因子;核因子 κB 受体活化因子配体;骨保护素;核因子 κB 受体活化因子/核因子 κB 受体活化因子配体/骨保护素信号转导;逆信号Research Progress of RANK/RANKL/OPG Signaling Pathway WANG Yan 1 ,LIU Chao 1 ,SONG Ren-gang 2 ,ZHANG Zhen-yu 1 . (1. First Department of ...
结论RANKL/RANK/OPG信号通路参与调控磷酸三钙磨损颗粒诱导假体周围骨溶解,通过给予外源性OPG能显著抑制磷酸三钙磨损颗粒诱导的骨溶解。 关键词:RANKL/RANK/OPG信号通路,磷酸三钙磨损颗粒,骨溶解 Abstract:ObjectiveTo investigate the role of RANKL/RANK/OPG signaling pathway in periprosthetic osteolysis induced by ...
结论 RANKURANK通路参与了乳腺癌耐药过程,其可能通过维持肿瘤干细胞群介导乳腺癌细胞耐药.%Objective To investigate the effect of RANKL/RANK (the receptor activator of nuclear factor κB ligand / receptor activator of nuclear factor κB,RANKL/RANK) signaling pathway on the drug resistance in breast ...
结论QGKSF可抑制RANKL诱导的RAW264.7细胞向破骨细胞分化,其机制可能是通过RANKL/RANK/OPG信号通路的调控作用而抑制破骨细胞过度分化,从而起到减轻RA骨破坏的作用。 【关键词】//强骨康疏方;类风湿关节炎;破骨细胞;RANKL/RANK/OPG...
In the recent two decades, it has been well elucidated that receptor activator of nuclear factor-κB ligand (RANKL; also known as TNFSF11) binding to its receptor RANK (also known as TNFRSF11A) drives osteoclast development as the crucial signaling pathway.1,2,3However, accumulating evidence ...
从ＯＰＧ⁃ＲＡＮＫＬ⁃ＲＡＮＫ通路到骨质疏松症分子靶向治疗 谢忠建 ［摘要］㊀在骨骼重塑过程中，成骨细胞和破骨细胞相互偶联是维持骨骼正常的关键，而这两种细胞的 偶联依赖于骨保护素（ｏｓｔｅｏｐｒｏｔｅｇｅｒｉｎ，ＯＰＧ）⁃核因子κＢ受体活化因子配体（ｒｅｃｅｐｔｏｒａｃｔｉｖａｔｏｒｏｆｎ...