导致 B 细胞数量显着减少 (47, 49);然而,这些影响可能是间接的,因为在小鼠中,B 细胞中 Rank 的组织特异性缺失【 tissue-specific deletion 】显示出 B 细胞的功能和发育没有差异,并且用Denosumab阻断 RANK/RANKL 不会明显影响骨质疏松...
OPG/RANKL/RANK pathway as a therapeutic target in cancer. J Thorac Oncol 2011;6:1468-73.McGrath EE. OPG/RANKL/RANK pathway as a therapeutic target in cancer. J Thorac Oncol. 2011;6(9):1468-73.McGrath EE: OPG/RANKL/RANK pathway as a therapeutic target in cancer. J Thorac Oncol 6: ...
(RANKL)信号通路是调节骨重建过程中破骨细胞功能的重要通路.成骨细胞释放的 RANKL 与破骨 细胞表面的 RANK 结合后通过 NF-Kβ途径,JNK 途径,蛋白激酶 B 途径等促进破骨细胞的分化和激活; OPG 则可竞争性抑制 RANK 与 RANKL 的结合,抑制破骨细胞功能,减少骨质破坏.OPG 与 RANKL 的 比例是调节骨吸收和骨形成...
and the mortality caused by osteoporosis and its complications has ranked fourth. The main reason for osteoporosis is that the balance between bone formation and bone absorption is broken. Nuclear factor receptor activator ligand/nuclear factor receptor activator (RANKL/RANK) pathway is the main conduc...
The RANK/RANKL/OPG signaling pathway is an important discovery of bone metabolism inrecent years. A lot of hormones,cytokines,growth factors influence bone metabolism by acting on receptoractivator of NF-κ B ligand(RANKL)and osteoprotegerin(OPG),which lead to metabolic bone diseases suchas ...
Understanding of osteoclast formation and activation has advanced considerably since the discovery of the RANKL/RANK/OPG system in the mid 1990s. Osteoblasts and stromal stem cells express receptor activator of NF-jB ligand (RANKL), which binds to its receptor, RANK, on the surface of osteoclasts...
Objective: To determine the role of the cytokine receptor activator of nuclear factor κ-Β ligand (RANKL); its receptor, receptor activator of nuclear factor κ-Β (RANK); and the RANKL/RANK pathway inhibitor RANK-Fc in leiomyoma growth. Design: Messenger RNA (mRNA) or protein levels of ...
目的:介绍 OPG/RANKL/RANK信号通路与骨巨细胞瘤发病机制的关系,总结并讨论OPG/RANKL/RANK信号通路在骨巨细胞瘤发病机制中的最新研究进展。 方法:检索 PubMed 数据库、Web of science数据库及万方数据库中2001至2019年相关文献,检索词分别为“OPG/RANKL/RANK,giant cell tumor of bone,pathogenesis,signal pathway, ...
The role of OPG/RANKL/RANK signaling pathway in the pathogenesis of giant-cell tumor of bone 背景:研究表明,骨保护素/核因子 κB 受体活化因子配体/核因子 κB 受体活化因子(OPG/RANKL/RANK) 信号通路与骨巨细胞瘤发病机制之间有一定的相关性,通过控制 OPG/RANK... Liang Chenliang,Zhao Zhenqun,Li Wanli...
pathway .%类风湿关节炎( rheumatoid arthritis ,RA)是一种慢性全身性自身免疫性疾病,临床上抑制RA患者关节周围及全身的骨量丢失是治疗的关键.研究表明炎症细胞因子( TNF-α,IL-1,IL-7,IL-17等)是刺激导致RA患者骨量丢失的重要介质,破骨细胞是参与骨吸收的主要细胞,RANKL/RANK信号途径是RA炎症导致骨量丢失的主要...