Estrogen is critical for skeletal homeostasis and regulates bone remodeling, in part, by modulating the expression of receptor activator of NF-κB ligand (RANKL), an essential cytokine for bone resorption by osteoclasts. RANKL can be produced by a variety of hematopoietic (e.g. T and B-cell)...
The RANK\\/ RANKL\\/ OPG interaction in the repair of autogenous bone grafts in female rats with estrogen deficiency Univ,Estadual,Paulista,... - 《Brazilian Oral Research》 被引量: 15发表: 2014年 Axon growth and recovery of function supported by human bone marrow stromal cells in the ...
However, the direct effects of AP on bone remodeling regulatory molecules, i.e. OPG and RANKL, in osteoblasts have not been reported. An increase in osteoblast population is an important requirement for therapeutic manipulation of growing bone. This study aimed to investigate the osteogenic ...
Tera Tde M, Prado RF, De Marco AC, et al.The RANK/RANKL/OPG interaction in the repair of autogenous bone graftsin female rats with estrogen deficiency [J]. Braz Oral Res, 2014,28(1):1-9.Tera Tde M, Prado RF, De Marco AC, Santamaria MP and Jardini MA: The ...
(A–C) Bone marrow macrophages were treated with M-CSF and RANKL to induce osteoclast differentiation. At the time of RANKL addition, cultures were also given no media, Krebs media not exposed to muscle (Control) or muscle conditioned media, with the volume of the latter two conditions equal...
The RANKL/OPG/RANK system In addition to inhibiting the activation of bone remodeling, estrogen also directly and indirectly suppresses bone resorption. It is this action of estrogen that is most closely linked to the immune system and cytokines traditionally associated with regulation of immune cells...
(b) Department of Diagnosis and Surgery, Instituto de Ciência e Tecnologia − ICT, Univ Estadual Paulista − UNESP, São José dos Campos, SP, Brazil.The RANK/ RANKL/ OPG interaction in the repair of autogenous bone grafts in female rats with estrogen deficiencyAbstract: The aim of ...
Estrogen and bone remodeling In addition to its role in female sexual development and reproductive physiology, estrogen plays a key role in bone cell metabolism. Estrogen contributes to the strength of a woman's skeleton by maintaining bone density. Bone is a dynamic tissue that is constantly ...
All these discoveries have generated new therapeutic possibilities based on the use of OPG and on inhibitors of the RANKL/RANK signaling pathway, not only for the treatment of postmenopausal bone loss, but also for other pathologies. Special mention should be made of the new therapeutic possibilitie...
This study contains limitations. First, we did not evaluate the possible underlying mechanism of sesame oil in the RANKL/RANK/OPG pathway, which is a crucial pathway involved in bone remodeling39and is considered as a therapeutic target in OVX rats40,41. Further studies are necessary to evaluat...