In rheumatoid arthritis, RANK ligand is also produced by inflammatory cells, including activated T- and B-cells, which are present in synovitis and in subchondral osteitis. By playing a central role in erosion formation, the osteoclast is not only responsible for functional handicap resulting from ...
Control mouse intestinal organoids and organoids cultured in the presence of recombinant mouse RANK ligand (rmRANKL, Oriental Yeast) for 12 h were dissociated with TrypLE (Thermo Fisher Scientific) and DNase I (Worthington Biochemical) for 5 min at 37 °C and subsequent vigorous pipetting...
they frequently experience longterm, treatment-related health problems, including osteopenia and osteonecrosis. Because some children present with fractures at ALL diagnosis, we considered the possibility that leukemic B cells contr...
RANKL (receptor activator of NF-κB ligand), its re- ceptor RANK, and the natural inhibitor osteoprotegerin (OPG) are essential for the development and activation of osteoclasts [4, 5]. Based on these findings, RANKL inhibition with a monoclonal antibody has been success- fully developed as a...
9 RegisterLog in Sign up with one click: Facebook Twitter Google Share on Facebook (redirected fromSpearman rank correlation) Spearman's rank correlation coefficient [¦spir·mənz ¦raŋk ‚kär·ə′lā·shən ‚kō·ə‚fish·ənt] ...
In concert, the present studies provide support for a model in which RANK signaling induces the interaction of PGC1β with NCoR/HDAC3 complexes on NF-κB/AP-1-containing enhancers or promoters in a manner that is dependent on the PGC1β RRM and RNAs. In this context, the dominant function...
The main aims of this study were: (1) to investigate whether a blockade of the interaction between the receptor activator of nuclear factor-κB (NF-ĸB) ligand (RANKL) and its receptor RANK may have potential as a novel therapeutic strategy for allergic asthma; (2) to compare the efficac...
IL-6 trans-signalling directly induces RANKL on fibroblast-like synovial cells and is involved in RANKL induction by TNF-alpha and IL-17. OBJECTIVES: We investigated the influence of cytokines on the expression of RANK ligand (RANKL) in fibroblast-like synoviocytes from RA patients (RA-FLS). ...
Moreover, Stat3-deficient bone marrow-derived macrophages showed an increased propensity to form osteoclasts in RANK-ligand (RANKL) cultures (Fig. 1a,b). These results suggest that Stat3 deficiency enables elevated responses to RANKL. Stat3 deficiency in hematopoietic cells also renders heightened TLR4...
First, the high levels of expression of RANK and its ligand in a large proportion of CC’s, the in vitro effects of RANKL inhibition on proliferation and the correlation with prognosis of high RANKL expression make it likely that there may be a direct antiproliferative effect on the tumor ...