Bisphosphonates and the receptor activator of nuclear factor kappa-B (RANK) ligand (RANKL) inhibitor denosumab inhibit osteoclast activity. Denosumab was more effective than zoledronic acid as shown in three prospective trials in solid tumors. These substances are therefore essential for...
The discovery of the receptor activator of nuclear factor-κB ligand (RANKL)/RANK/osteoprotegerin (OPG) system and its role in the regulation of bone resorption exemplifies how both serendipity and a logic-based approach can identify factors that regulate cell function. Before this discovery in the...
蛋白别名: CD254; H-RANK-L; M-Rank-L; ODF; OPG ligand; OPGL; Osteoclast differentiation factor; Osteoprotegerin ligand; rank-l; RANKL; receptor activator of NF-kappaB ligand; receptor activator of nuclear factor kappa B ligand; Receptor activator of nuclear factor kappa-B ligand; ...
Multinucleated bone-resorbing osteoclasts (Ocl) are cells of hematopoietic origin that play a major role in osteo-porosis pathophysiology. Ocl survival and activity require M-CSF and RANK ligand (RANKL). M-CSF signals to Akt, while RANKL, like TNFα, activates NF-κB. We show here that alt...
RANK ligand (RANKL), a member of the tumor necrosis factor (TNF) cytokine family, is required for differentiation, activation, and survival of osteoclasts and thus plays a critical role in cancer-induced bone disease. Under normal circumstances, RANKL activity is attenuated by its endogenous ...
牙周炎是以牙槽骨吸收为主要特征的慢性炎症,至今对其发病机制的认识仍不十分清楚,随着对RANKL/RANK/OPG研究的深入,发现RANKL/RANK/OPG在牙周炎发病机制中起重要作用。 1 RANKL/RANK/OPG调节系统 1.1 RANKL RANKL(receptor activator of nuclear factor-κB ligand)又称TRANCE(TNF-related activation-induc...
(1)本研究首次构建新型rankl阻断剂(rank胞外段蛋白)的巴斯德毕赤酵母(pichiapastoris),保藏于中国微生物菌种保藏管理委员会普通微生物中心(cgmcc),保藏地址:北京市朝阳区北辰西路1号院3号,编号为cgmccno.12500,于2016年05月26日保藏)表达系统,获得多拷贝阳性酵母转化菌株,建立超滤—sephadexg-50—qsepharoseff的纯化...
In addition, the serum level of sRANKL was shown to be a significant risk predictor of type 2 diabetes mellitus (T2DM) in a large prospective study30. Therefore, the selective sRANKL inhibitor may avoid immune side effects. A small molecule that can selectively inhibit sRANKL-RANK interactions...
【5】RANK(TNFRSF11A、OFE、ODFR、TRANCE-R、ODAR、CD265)(4、12、13)和 RANKL(TNFSF11、TRANCE、ODF 和 OPGL)(14-17)是 TNF 受体的受体-配体对【receptor-ligand pair】超家族,是在上个千年末【last millennium】发现的,被确定...
RANKL (receptor activator of NF-κB ligand), its re- ceptor RANK, and the natural inhibitor osteoprotegerin (OPG) are essential for the development and activation of osteoclasts [4, 5]. Based on these findings, RANKL inhibition with a monoclonal antibody has been success- fully developed as a...