Results indicate that for lipid synthesis in the neonatal lung, acetyl CoA from AcAc is derived predominantly from a cytoplasmic pathway involving AcAcCoA synthetase and AcAcCoA thiolase, whereas citrate is the major route of acetyl group transfer from glucose. Lipogenesis from βOHB involves both ...
Why is pyruvate converted into acetyl CoA prior to entering the Krebs Cycle? What does this conversion do to the pyruvate molecules? The Krebs Cycle: The Krebs Cycle (also known as the citric acid cycle) refers to the serious of process...
The energetics of the reaction from phosphoenolpyruvate to form pyruvate are such that this is essentially an irreversible process, as is the breakdown of pyruvate to acetyl-CoA. An alternate pathway to effect a reversal of this process is available. Through a carbon dioxide fixation reaction in ...
The latter is converted to malate by mitochondrial malate dehydrogenase. Roles of pyruvate, NADH, and mitochondrial complex I in redox balance and imbalance in [beta] cell function and dysfunction Effects of biotin on pyruvate carboxylase, acetyl-CoA carboxylase, propionyl-CoA carboxylase, and markers...
The pyruvate dehydrogenase complex (PDC) catalyzes the irreversible decarboxylation of pyruvate into acetyl-CoA. PDC deficiency can be caused by alterations in any of the genes encoding its several subunits. The resulting phenotype, though very heterogeneous, mainly affects the central nervous system. ...
Pyruvate carboxylase (PC) was purified to homogeneity from an overexpressing strain of the purple photosynthetic bacterium Rhodobacter capsulatus using a rapid dye-ligand affinity chromatography procedure, in which dye-bound enzyme was specifically eluted with a low concentration of acetyl-CoA, an alloste...
Endogenous pyruvate decarboxylase activity in yeast converts pyruvate to acetaldehyde, which is then converted to ethanol or to acetyl-CoA via acetate (see FIG. 1). Yeasts may have one or more genes encoding pyruvate decarboylase. For example, there is one gene encoding pyruvate decarboxylase in...
Pyruvate then undergoes pyruvate oxidation to produce acetyl CoA, an intermediate in the Krebs cycle. The Krebs cycle, also known as the citric acid cycle, is another biochemical pathway that produces high-energy intermediates. Both glycolysis and the Krebs cycle are pathways that exist for the ...
Instead acetyl-CoA was converted to acetoacetate by reactions which may favour the pathway catalyzed by acetoacetyl-CoA thiolase and 3-oxoacid-CoA transferase. Acetate, acetyl- and palmitoyl-carnitine inhibited the decarboxylation of [1-14C] pyruvate. These observations may be connected with the ...
Methylmercury toxicity is intensified by promoting the transport of pyruvate into mitochon- dria. Pyruvate is produced in the cytoplasm and is then transported into the mitochondria, where it is converted to acetyl-CoA; acetyl-CoA subsequently reacts with oxaloacetate to form citrate, thus ...