Acetyl-CoAE. coliPyruvatePyruvate dehydrogenasePyruvate formate lyaseSuccinic acidEfficient succinate production in Escherichia coli is attained during anaerobic glucose fermentation in biosynthetic processes combining the reductive branch of the TCA cycle and the glyoxylate bypass. Pyruvate dehydrogenase (PDH) ...
and into the matrix where they can either be oxidized and combined with coenzyme A to form CO2, acetyl-CoA, and NADH, or they can be carboxylated (by pyruvate carboxylase) to form oxaloacetate. This latter reaction "fills up" the amount of...
Acetyl-CoA was also effective in protecting the enzyme from thermal denaturation. The enzyme was inhibited by 2-oxoglutarate and, to a lesser extent, L-aspartate, with sigmoidal kinetics with respect to acetyl-CoA concentration. The amino acid composition, pH optimum and kinetic constants for ...
Roles of pyruvate, NADH, and mitochondrial complex I in redox balance and imbalance in [beta] cell function and dysfunction Effects of biotin on pyruvate carboxylase, acetyl-CoA carboxylase, propionyl-CoA carboxylase, and markers for glucose and lipid homeostasis in type 2 diabetic patients and non...
When grown with pyruvate, the pyruvate:Fd oxidoreductase (also known as PFOR or pyruvate synthase) likely serves as the major point of input of electrons into the soluble low-potential electron pool and thereby into CEF. During fermentative growth, acetyl-CoA synthetase can convert acetyl-CoA to...
The purified enzyme was absolutely dependent on ATP, Mg2+ (or Mn2+ or Co2+), pyruvate, and bicarbonate for activity; phosphoenolpyruvate could not replace pyruvate, and acetyl-CoA was not required. The enzyme was inhibited by ADP and alpha-ketoglutarate but not by aspartate or glutamate. ATP ...
In order for the Krebs cycle to take place, pyruvate must be converted to acetyl-CoA. Answer and Explanation: Become a Study.com member to unlock this answer! Create your account View this answer Pyruvate is converted into acetyl-CoA...
Ashman, L. K., Wallace, J. C., and Keech, D. B. (1973) Densitization of pyruvate carboxylase against acetyl-CoA stimulation by chemical modification. Biochem. Biophys. Res. Commun. 51, 924-931.Ashman LK, Wallace JC, Keech DB. Densitization of pyruvate carboxylase against acetyl-CoA ...
The pyruvate dehydrogenase complex (PDHC) catalyzes the irreversible oxidation of pyruvate to acetyl CoA according to the reaction: $$Pyruvate + NA{{D}^{+}}+CoASHo Acetyl CoA + NADH + C{{O}_{2}}$$ The acetyl CoA formed is then either oxidized in the tricarboxylic acid cycle or used ...
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