GFP expression in Pv-cre mice injected with AAV-LS1L-GFP is stable for months.Sandra, J. KuhlmanZ., Josh Huang
然后,eCBs可能会逆行激活PV+神经元末端的CB1R,减少GABA在LA主要神经元上的释放,导致印记细胞群大小和恐惧记忆泛化的增加[Fig.4]。 此外,研究人员还开发了一种新的Cre依赖性CRISPR-Cas9策略,专门在LA PV+神经细胞中敲除CB1R。结果表...
Conditional activation of a single-copy L1 transgene in mice by Cre. Genesis 46, 373–383 (2008). CAS PubMed PubMed Central Google Scholar Campbell, B. C. et al. mGreenLantern: a bright monomeric fluorescent protein with rapid expression and cell filling properties for neuronal imaging. ...
Mice were head fixed while placed on a running wheel and passively viewed full-field drifting-grating stimuli. To record from specific GABAergic interneuron subtypes, we crossed the PV- and Sst-Cre lines to the Ai32 line, yielding expression of channelrhodopsin-2 (ChR2) in either PV or Sst...
图1. PV-Cre;Hrh2fl/fl小鼠表现出多动、冲动和注意缺陷。 进一步,为了明确PV神经元上H2R与ADHD的关系,研究人员对ADHD模型小鼠和有ADHD症状的患者脑样本的PV神经元上H2R表达进行研究(图2)。 研究发现,SNr脑区PV神经元上H2R表达量显著性下降,提示SNr PV神经元的H2R低表达可能与ADHD相关。
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Arteriogenesis on demand in exercising mice expressing FGF-2 under the control of the phosphoglycerate kinase promoter the pgk gene promoter pgk shortcut of less than 500 base pairs of the proximal end of the 5 'region of the pgk gene.the invention also provides for vehicles capable of replicat...
Conditional deletion of Stat3 in mTECs, achieved by crossing Stat3fl/fl mice with K5.Cre mice, leads to a decrease in mTEC ... M Jain,D Lomada,M Reddy,... - 《Journal of Immunology》 被引量: 0发表: 2011年 Regenerative and fibrotic pathways in canine hepatic portosystemic shunt and ...
Among these, the Cre/LoxP system is the most popular in mice, with the two commonly used PV-Cre lines cited over 5600 times. Here we report in the mouse cerebellar cortex that PV-Cre activity is not restricted to inhibitory neurons. Imaging of Cre-activated reporters demonstrated recombination...