T Cells Mediate the Effects of PTH in BoneParathyroid hormone (PTH) causes bone loss when produced in a continuous fashion. However, PTH induces a potent bone anabolic effect when injected intermittently. The mechanism of action of PTH remains largely unknown. This article reviews the evidence in...
The mechanism of action of angiostatin: can you teach an old dog new tricks? What is angiostatin? In 1994, Folkman and colleagues published a landmark paper describing anti-tumor effects in mice with a purified fragment of plasminog... Moser, Tammy,Stack, M.,Wahl, Miriam,... - 《Thromb...
Iannotti JP, Brighton CT, Iannotti V, Ohishi T: Mechanism of action of parathyroid hormone-induced proteoglycan synthesis in the growth plate chondrocyte. J Orthop Res. 1990, 8 (1): 136-145. Article PubMed CAS Google Scholar Lagerstrom MC, Hellstrom AR, Gloriam DE, Larsson TP, Schioth...
We also show that integrin α6β4 expression is modulated at the mRNA level, indicating a transcriptional and/or post-transcriptional mechanism of action for PTHrP. PTHrP expression also increased the levels of phosphorylated Akt, with a consequent increase in the levels of phosphorylated (inactive)...
These findings raised the hypothesis that RGS14 stabilizes the NHERF1–NPT2A binary complex, accounting for or contributing to its mechanism of action. To test this idea, we performed co-IP experiments (Fig. 7) using host opossum kidney (OK) cells, the accepted standard model for PTH-...
Studies and the involving b2 the adrenergic mechanism of action of PCO371 on PTHR1 will provide useful insights into the mechanism of activation of class B GPCRs. In conclusion, the small-molecule PTHR1 agonist PCO371 is a compound with potential to be developed and used as an orally ...
(PTH) on rat bone metabolism were first observed in the early 1900s.1–3 Since the achievement of the chemical synthesis of human PTH (1–34) in the 1970s, studies have attempted to define the detailed mechanism of this hormonal action.4 The ana- bolic effect of PTH on the skeleton ...
PTHrP can interact with this receptor to enhance human platelet activation induced by several agonists through a MAPK-dependent mechanism 6. Localization of PTHrP in breast cancer metastases: PTHrP has recently been identified in 60% of a series of primary breast cancers. The detection of a bone-...
Unfortunately, this mechanism is already at work in some metropolitan areas. D. The promoters of New Towns so far in the United States have been developers, builders, and financial institutions. The main interest of these promoters is economic gain. Furthermore, federal regulations designed...
Dempster et al., “On the Mechanism of Cancellous Bone Preservation in Postmenopausal Women with Mild Primary Hyperparathyroidism,” J. Clin. Endocrinol. Metab. 84: 1562-1566 (1999). Ding et al., “A Single Amino Acid Determines the Immunostimulatory Activity of Interleukin 10,” J. Exp. Me...