Insufficiency of PTH action on bone in uremia. Kidney Int Suppl 2006:S34-6. DOI: http://dx.doi. org/10.1038/sj.ki.5001600Iwasaki, Y., Yamato, H., Nii-Kono, T., Fujieda, A., Uchida, M., Hosokawa, A., Motojima, M. & Fukagawa, M. (2006) Insuf- ficiency of PTH action on ...
or with infusion of PTH in rodents. We have previously shown that the chemokine, monocyte chemoattractant protein-1 (MCP-1), is a mediator of PTH’s anabolic effects on bone. To determine its role in PTH’s catabolic effects, we continuously infused female wild-type (WT) and...
An intact N terminus is required for the anabolic action of parathyroid hormone on adult female rats. J Bone Miner Res. 1997;12:384–92. doi:10.1359/jbmr.1997.12.3.384. Article CAS PubMed Google Scholar Ogata N, Shinoda Y, Wettschureck N, Offermanns S, Takeda S, Nakamura K, et al....
Parathyroid Hormone (PTH) plays a crucial role in the maintenance of calcium homeostasis directly acting on bone and kidneys and indirectly on the intestine. However, a large family of PTH-related peptides exists that exerts other physiological effects on different tissues and organs, such as the...
New signaling pathway for parathyroid hormone and cyclic AMP action on extracellular-regulated kinase and cell proliferation in bone cells. Checkpoint of modulation by cyclic AMP 2002, Journal of Biological Chemistry Citation Excerpt : 1) The pattern of internal production or external dosing of PTH in...
FGF2 crosstalk with Wnt signaling in mediating the anabolic action of PTH on bone formation 来自 Semantic Scholar 喜欢 0 阅读量: 75 作者:L Xiao,Y Fei,MM Hurley 摘要: The mechanisms of the anabolic effect of parathyroid hormone (PTH) in bone are not fully defined. The bone anabolic effects...
Antagonizing microRNA‐19a/b augments PTH anabolic action and restores bone mass in osteoporosis in mice Topics include the role of osteocytes in bone remodeling and as regulators of osteoclastic bone resorption, the key players in the anabolic and catabolic actions of parathyroid hormone (PTH), ...
❖HowdoesPTHactionsinourbody?CompanyLogo HotTip www.1kejian.com Forexample:hyperparathyroidism(甲亢)Althoughinthisdiseasebonecatabolismprevailsonboneanabolism,PTHremainsapotentstimulatorofosteoblastsanditsanabolicpropertiescanbeseenwhenitisgivenatalowdosageandintermittently.WHYMUSTINALOWDOSAGE?CompanyLogo Anabolicwindow...
It has been known for over a decade that PTH can exert its anabolic or catabolic effect on bone via activation of the PPR widely expressed on cells of the osteoblast lineage; however, the exact cellular target of its action on bone has remained elusive. Several mechanisms have been proposed,...
Drugs Used to Treat Osteoporosis: The Critical Need for a Uniform Nomenclature Based on Their Action on Bone Remodeling There continues to be uncertainty about the classification of available drugs for treating osteoporosis. We find that grouping them into anti-catabolic and... BL Riggs,AM Parfitt...