Bone homeostasis is a dynamic equilibrium which is associated with bone formation mediated by osteoblasts and bone resorption mediated by osteoclasts.Intermittent PTH treatment increase bone formation by enhancing osteoblast number and activity.Studies in vivo and in vitro have shown that the cellular ...
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Bone homeostasis is a dynamic equilibrium which is associated with bone formation mediated by osteoblasts and bone resorption mediated by osteoclasts.Intermittent PTH treatment increase bone formation by enhancing osteoblast number and activity.Studies in vivo and in vitro have shown that the cellular mech...
This review considers many new basic and clinical aspects of parathyroid hormone (PTH). We focus especially on the identification of PTH fragments and how ... PA Friedman,WG Goodman - 《Am J Physiol Renal Physiol》 被引量: 113发表: 2006年 Human PTH-(7-84) inhibits bone resorption in vitr...
Bone remodelling in vertebrates is coordinately regulated by the opposing effects of parathyroid hormone (PTH) and transforming growth factor-beta (TGF-). PTH couples the processes of bone resorption and formation by enforcing simultaneous internalization of TGF- type II receptor (TRII) and PTH type...
Effects of alfacalcidol on cancellous and cortical bone mass in rats treated with glucocorticoid: a bone histomorphometry study. The beneficial effects of alfacalcidol (ALF) on bone mass, bone formation, and bone resorption have been established in ovariectomized rats. Our previous s... Jun,Iwamoto...
Osteoporosis is characterized by low bone mineral density and/or poor bone microarchitecture leading to an increased risk of fractures. The skeletal alterations in osteoporosis are a consequence of a relative deficit of bone formation compared to bone resorption. Osteoporosis therapies have mostly relied...
Parathyroid hormone (PTH) is a potential medicine for osteoporosis, and subcutaneous (sc) PTH treatment enhances bone mass; however, continuous infusion of PTH elicits bone resorption and induces bone loss. To clarify this contradictory phenomenon, we examined bone markers and bone mass in rats to...
Effects of transforming growth factor-α on parathyroid hormone- and parathyroid hormone-related protein- mediated bone resorption and adenylate cyclase st... The effects of transforming growth factor-α (TGFα) were determined on the ability of parathyroid hormone (PTH) or parathyroid hormone-related...
The binding of RANKL to RANK stimulates these precursors to fuse, forming new osteoclasts which ultimately enhances the resorption of bone. In the kidney- It enhances active reabsorption of calcium from distal tubules and the thick ascending limb.In the intestine- It enhances the absorption of ...