2024年12月16日,复旦大学脑科学研究院/脑功能与脑疾病重点实验室高艳琴教授团队联合许智祥研究员团队,在Advanced Science上发表题为《逆转创伤性脑损伤后的持续性 PTEN 激活可通过 Akt/mTORC1 信号级联促进长期轴突再生》(“Reversing Persistent PTEN Activation After Traumatic Brain Injury Fuels Long-Term Axonal Rege...
而 PTEN过表达后， 卡博替尼的抗肿瘤作用得到了增强，在 PTEN表达 降低后，卡博替尼的抗肿瘤作用出现了减弱，表明 PTEN的表达与卡博替尼的抗肿瘤作用可能存在 协同效应，有可能成为未来治疗e R C C 的新策略。
com 收稿日期: 2020 -05 -15Hippo 信号通路介导 PTEN 调节 PI3K/AKT/mTOR 信号通路影响肝癌细胞增殖能力徐 瑞1 ,李丽娜 1 ,王文娟2*(1 陕西省肿瘤医院内一科,西安 710061; 2 西安交通大学第一附属医院肿瘤内科; * 通讯作者, E-mail:lingyinnancy@163. com )摘要: 目的 研究 Hippo 信号通路下游效应分子 ...
PTEN/AKT/mTORAutophagyAutophagy is a double-edged sword during the initiation and progression of multiple tumors. The Hippo pathway effector YAP has been proved to be involved in autophagy processes. The present study aimed to investigate how YAP regulates cell proliferation via autophagy in lung ...
摘要:探讨少腹逐瘀汤对子宫内膜异位症纤维化模型小鼠的保护作用,并从第10号染色体缺失的磷酸酶和张力蛋白同源物(phosphatase and tensin homolog deleted on chromosome ten, PTEN)/蛋白激酶B(protein kinase B,Akt)/哺乳动物雷帕霉素靶蛋白(mammalian target of rapamycin, mTOR)信号通路探讨其作用机制。将85只BALB...
Finally, we demonstrated that miR-206 prevents cancer progression in EC by downregulating HDAC6 via the PTEN/AKT/mTOR pathway. Our results suggest that miR-206 and HDAC6 play critical roles in EC development and may be innovative diagnostic markers and therapeutic targets for EC. Materials and ...
愈障Ⅱ号方能激活再障模型小鼠骨髓造血细胞被抑制的PTEN/AKT/m TOR信号通路,促进造血细胞的增殖,抑制造血细胞的凋亡,从而改善骨髓造血功能.4.补肾组与调和肝脾组对骨髓造血干细胞比例,造血细胞凋亡率与m TOR信号通路活性影响方面多有相似又各有侧重,提示愈障Ⅱ号方对再障的治疗作用是多环节,多靶点的,PTEN/AKT/m ...
(Fig.4E)这些结果表明,m6A在调节癌症通路如PI3K/Akt/mTOR通路中发挥着重要作用。 Fig.4 05 m6A失调对胃肠道肿瘤PI3K/Akt/mTOR通路的影响 通过分析GEO数据库中METTL3 KD数据集,发现METTL3的敲低会导致PI3K/AKT/MAKR信号通路蛋白AKT1、AKT2、PTEN、PIK3CA和BCL2表达相对升高 ( Fig.5A ) 。 Hela和A549细胞中...
PI3K/Akt signaling pathway, is both required and capable of providing enough protection to the heart against harm caused by I/R. Moreover, the signaling pathways that involve PI3K/Akt/Erk/PTEN/mTOR play a crucial role in facilitating the proliferation and maintenance of neurons following an ...
Alpha1-ACT functions as a tumour suppressor in hepatocellular carcinoma by inhibiting the PI3K/AKT/mTOR signalling pathway via activation of PTEN. Cell Physiol Biochem. 2017;41:2289–2306. (Open in a new window)PubMed(Open in a new window)Google Scholar...