PTBP1 is universally expressed in various tissues and binds to multiple downstream transcripts to interfere with physiological and pathological processes such as the tumor growth, body metabolism, cardiovascular
polypyrimidine tract binding protein 1 or PTBP1, has been shown to play a critical role in cancer progression (e.g., breast, colon and bladder cancer) [8,9,10]. As its name suggests, PTBP1 originally binds to polypyrimidine tract regions of introns for messenger RNA processing. PTBP1 func...
Knockdown of PTBP1 in vivo reduced the pro-tumorigenic effects of senescence without increasing the risk of tumor initiation. These findings suggest that targeting the pro-inflammatory SASP is a safe and effective therapeutic strategy that can be employed against inflammation-driven cancers such as ...
Under hypoxic conditions, plasma levels of lactate in mice increase alongside the expression of several inflammatory cytokines, such as IL-6, resulting in kidney injury14. Lactate levels are associated with changes in the gut microbiota and may have a critical role in disease regulation. As nano-...
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive and incurable disease. Poor prognosis is due to multiple reasons, including acquisition of resistance to gemcitabine, the first-line chemotherapeutic approach. Thus, there is a strong need for nove
Moreover, we could identify a number of other RBPs that are predicted to bind to the CD19 locus being deregulated in leukemic blasts, including NONO. Their expression is highly heterogeneous across B-ALL molecular subtypes as shown by analyzing 706 B-ALL samples accessed via the St. Jude ...
Splicing factors involve a large variety of RNA-binding proteins (RBPs), such as heterogeneous nuclear ribonucleoproteins (hnRNPs) and serine/arginine-rich (SR) proteins [16]. Here we found PTBP1 (also known as hnRNP I) was capable of binding the pre-mRNA ofITSN1and silencing PTBP1 remarka...
Dysfunction of podocytes has been regarded as an important early pathologic characteristic of diabetic kidney disease (DKD), but the regulatory role of long noncoding RNAs (lncRNAs) in this process remains largely unknown. Here, we performed RNA sequenci
Knockdown of PTBP1 or circRNA_001160 significantly increased BTB permeability, respectively. As a molecular sponge of miR-195-5p, circRNA_001160 attenuated its negative regulation of the target gene ETV1 by adsorbing miR-195-5p. In addition, ETV1 was overexpression in GECs. ETV1 bounded to the...
we adopted the AC protocol for the induction of DE in the subsequent study. As verified by qRT-PCR, the expression of the DE-specific genesSOX17,FOXA2, andCXCR45were remarkably elevated during DE differentiation (Fig.1a). Meanwhile, the expression of mesendoderm-related genes, such asEOMES...