前列腺特异性膜抗原(PSMA)在mCRPC中显著高表达,被认为是一种在免疫治疗领域具有良好前景的肿瘤相关抗原。 目前观点认为mCRPC中CAR-T治疗的主要障碍是其免疫抑制性肿瘤微环境,尤其是其微环境中显著高水平的TGFβ大大限制了CAR-T细胞发挥治疗作用的潜力。
Sixteenpatients suspected of PCa were scanned by 68 Ga-PSMA-11and 68 Ga-P137 PET/CT, respectively, followed by prospectiveanalysis. The tumor-to-background ratio was calculated using normalprostate tissue, blood pool, muscle, and urine as backgrounds. Pathologyor follow-up results were used to...