血清 中 PSA主要以结合型 PSA(TPSA)和游离型 PSA(FPSA)形式存 在,其中 FPSA占总 PSA(TPSA)的10% ～20%.有关研究发现, 前列腺癌患者血清 FPSA/TPSA水平显著低于前列腺增生患者, 为 FPSA/TPSA诊 断前列腺癌提供依据 .[10 11] 本研究结果显示,前列腺癌患者血清 TPSA水平显著高于前列腺增生患者,血清 FPSA...
其次,使用前列腺靶向示踪剂(如前列腺特异性膜抗原[PSMA])的正电子发射断层扫描(PET)已越来越多地用于对新诊断的PCa进行分期,并在一些地区得到批准。虽然PET对淋巴结分期的敏感性可能并不理想,但对于相当一部分通过常规手段识别的局部前列腺癌患者(20-45%,取决于患者人群),PET在常规成像未检测到的淋巴结中表现出高...
4H). Collectively, Thr163 PSA was associated with highest metastatic tumour burden, including bone metastases, which is consistent with our observations for the behaviour of these cells in-vitro, suggestive of a relationship with the poor prognosis of the patients, carrying the rs17632542 SNP, ...
A multicenter study of nonmetastatic castration-resistant prostate cancer (nmCRPC) was conducted to identify the optimal cut-off value of prostate-specific antigen (PSA) doubling time (PSADT) that correlated with the prognosis in Japanese nmCRPC. Of the 515 patients diagnosed and treated for nmCRPC...
3,4 The prognosis for low- and intermediate-risk localized prostate cancer is excellent,5 and although there is fair-quality evidence that screening by PSA testing reduces prostate cancer deaths,6 debate continues about the trade-off between the mortality benefit and risks of harm from over...
Although PSA bounce can be of concern for both the patient and physician, paradoxically, it is often associated with an improved prognosis (Patel et al, 2004; Ciezki et al, 2006; Mitchell et al, 2008; Bernstein et al, 2013). To date, no satisfactory explanation for this phenomenon has ...
The over⁃expression of Bax⁃α plays an important role in the development of prostate cancer. Detection of serum PSA,TNF⁃α and Bax⁃α level shows clini⁃ cal value for diagnosis,treatment and prognosis prediction of prostate cancer. 【 Key words】 prostate cancer; prostatic specific ...
In general, however, the study concluded that massive screening and PSA awareness efforts during the 1990s and early 2000s resulted in substantial shifts toward earlier-stage disease and fewer cases of metastases at diagnosis. In the United States over the most recent 20 years, Messing said, pros...
More frequent Ra-223 treatment has also been associated with a better prognosis8. Regarding safety, Ra-223 treatment was well tolerated, and severe adverse events are unlikely to occur if the appropriate criteria for radiopharmaceutical administration are met. In the current study, only one patient...
prognosis and staging of this cancer3,14,36,37,38,39,40,41. Some of these new diagnostic tools are related to PSA, such as PHI21,40, 4 K Score19,20and the STHLM3 test23,24, or RCs to assess the PCa risk of a patient25. However, their clinical applicability is controversial an...