原始致癌基因c-Rel 相关内容 a坚守内心 动力 Perseveres the innermost feelings power[translate] a每天按时吃饭并且吃足够的食物 正在翻译,请等待...[translate] aASSITANCE ASSITANCE[translate] aFig.5 Polarization curves of coatings in 3 5% NaC1 涂层极化曲线在3 5% NaC1[translate] ...
The c-rel protooncogene product represses NF-kappa B p65-mediated transcriptional activation of the long terminal repeat of type 1 human immunodeficiency virus. Proc Natl Acad Sci U S A. 1993 Feb 1; 90 (3):1023–1027.Doerre S, Sista P, Sun SC, Ballard DW, Greene WC. The c-rel ...
Background: The proto-oncogene product c-Rel is a Rel/NF-κB family transcription factor that plays a critical role in lymphoid cell development and mediates CD28-induced expression of interleukin 2 (IL-2). The CD28 response element (CD28RE) in the IL-2 enhancer is nonameric and similar to...
1、 因易位使原癌基因与另一基因形成融合基因,产生一个具有致癌活性的融合蛋白, 如t(9:22)使c-abl与bcr融合,产生一个致癌的P210蛋白 2、因易位面使原癌基因表达失控,如t(8:14)易位使c-myc表达失控. (三)基因扩增 基因扩增(gene amplification)即基因拷贝数增加. 如HL-60和其它白血病细胞,C-myc扩增8-22...
Proto-oncogene c-Akt Proto-oncogene c-Cot proto-oncogene c-ErbB-1 Proto-oncogene c-ErbB-2 Proto-oncogene c-Fgr proto-oncogene c-Fos proto-oncogene c-Fos Proto-oncogene c-Fyn Proto-oncogene c-Fyn Proto-oncogene c-Fyn Proto-oncogene c-Jun proto-oncogene c-Rel proto-oncogene c-Rel proto-...
The mammalian NF-κB protein family consists of five structurally similar REL proteins (RelA, RelB, c-Rel, NFkB1 and NFkB2 genes), each possessing a REL homology domain (RHD) to allow the dimerisation of subunits and the interaction of the dimers with target sites on DNA [21]. Addition...
The mammalian NF-κB protein family consists of five structurally similar REL proteins (RelA, RelB, c-Rel, NFkB1 and NFkB2 genes), each possessing a REL homology domain (RHD) to allow the dimerisation of subunits and the interaction of the dimers with target sites on DNA [21]. Addition...
Here, we report that the proto-oncogene c-maf, a basic region/leucine zipper transcription factor, controls tissue-specific expression of IL-4. c-Maf is expressed in Th2 but not Th1 clones and is induced during normal precursor cell differentiation along a Th2 but not Th1 lineage. c-Maf ...
Rheumatoid synovial T lymphocytes were investigated for the presence of mRNA for the cytokines interleukin-2, -3, -4, -6, interferon-gamma, the interleukin-2 receptor (CD25) and the proto-oncogene c-myc. The isolated RNAs were analysed by dot blot and Northern blot hybridization. Our results...
A. , The c-re/ protooncogene product c-Rel but not NF- kappa B binds to the intronic region of the human interferon-gamma gene at a site related to an interferon-stimnulatable response element . Proc. nat. Acad. Sci. (Wash.) 89 , 1740 – 1744 ( 1992 )....