DNA描述 Homo sapiens RELA proto-oncogene, NF-kB subunit (RELA), transcript variant 1, mRNA DNA大小: 2517 bp DNA编码区: atggacgaactgttccccctcatcttcccggcagagccagcccaggcctctggcccctat gtggagatcattgagcagcccaagcagcggggcatgcgcttccgctacaagtgcgagggg cgctccgcgggcagcatcccaggcgagaggagcacagataccaccaagaccca...
genitourinary system; musculature; and skin. Human ortholog(s) of this gene implicated in ductal carcinoma in situ; lung non-small cell carcinoma; lymphoma; and renal cell carcinoma. Orthologous to human RELA (RELA proto-oncogene, NF-kB subunit). [provided by Alliance of Genome Resources, Apr...
), transcription regulation, lung disease, mucosal injury, RELA proto-oncogene, Wnt, ZEBThe epithelial-mesenchymal transition (EMT) is a multistep dedifferentiation program important in tissue repair. Here, we examined the role of the transcriptional regulator NFkB in EMT of human primary small ...
Both of these subunits exhibit sequence homology to the protooncogene c-Rel. The p50/p65 heterodimer remains in the cytosol in an inactive form as a complex with its inhibitor,IkB. Upon stimulation of cells by a wide variety of stimuli such as lipopolysaccharide (LPS),pro-inflammatory cytokines...
We noticed that some RELAFUS1 peaks (TSS ± 10 kb) overlapped with SE regions that were annotated to well-known cancer-associated genes such as CCND1 (a representative NF-κB target gene) [14, 15], PIK3R2 (proto-oncogene), DOT1L (histone modifier gene) in addition to ...
蛋白别名: BCD541; C-Rel protein; C-Rel proto-oncogene protein; gemin 1; gemin-1; proto-oncogene c-Rel; SMA; SMA1; SMA2; SMA3; SMA4; SMN; SMN2; SMNT 基因别名: c-Rel Entrez Gene ID: (Mouse) 19696 功能 RNA polymerase II regulatory region sequence-specific DNA binding RNA ...
nf-kappa-b是一种广泛存在的转录因子,参与多种生物学过程。它被特定的抑制剂以非活性状态保存在细胞质中。当抑制剂降解时,nf-kappa-b移向细胞核并激活特定基因的转录。nf-kappa-b由结合到rel、rela或relb的nfkb1或nfkb2组成。nf-kappa-b最丰富的形式是nfkb1与该基因的产物
The ETS proto-oncogene 1 (Ets1) has versatile roles during the cellular processes of cancer development. It is often highly expressed in breast cancers and mediates migration and invasion of human breast cancer cells. However, underlying mechanisms ofgene expression is still ambiguous. Here, we ...
Aberrant overexpression of the c-rel protooncogene is associated with lymphoid malignancy, while c-rel deletion produces severe lymphoproliferative defects... Shuhua,Cheng,Constance,... - 《Oncogene》 被引量: 99发表: 2003年 Strength of molecular complexation of apolar solutes in water and in organic...
The v-rel avian reticuloendotheliosis viral oncogene homolog A (RELA) gene encodes the major component of the NF-kB complex. We genotyped four single-nucleotide polymorphisms (SNPs) in the RELA gene and performed a gene-based association analysis using 1224 patients with schizophrenia and 1663 ...