REL(REL proto-oncogene, NF-kB subunit) 该基因编码一种属于rel同源域/免疫球蛋白样折叠、丛蛋白、转录因子(rhd/ipt)家族的蛋白质。这个家族的成员调节参与细胞凋亡、炎症、免疫反应和致癌过程的基因。这种原癌基因在B淋巴细胞的存活和增殖中起作用。这种基因的突变或扩增与B细胞淋巴瘤,包括霍奇金淋巴瘤有关。该...
(REL proto-oncogene, NF-kB subunit) 该基因编码一种属于rel同源域/免疫球蛋白样折叠、丛蛋白、转录因子(rhd/ipt)家族的蛋白质。这个家族的成员调节参与细胞凋亡、炎症、免疫反应和致癌过程的基因。这种原癌基因在B淋巴细胞的存活和增殖中起作用。这种基因的突变或扩增与B细胞淋巴瘤,包括霍奇金淋巴瘤有关。该...
抗体名称 Anti-c-Rel/REL Antibody 指标别名 REL?proto-oncogene;NF-kB subunit;C-Rel 克隆性 Monoclonal 检验物种 human 应用范围 WB,IP 基因名称 REL 抗体来源 Rabbit 抗体类型 IgG 免疫原 A synthesized peptide derived from human c-Rel c-Rel contains an amino-terminal DNA-binding domain referred to ...
Gene NameREL proto-oncogene, NF-kB subunit Gene SymbolREL SynonymsC-Rel; IMD92; HIVEN86A OrganismHuman Gene ID5966 UniProt IDQ04864 Main Accession No.NM_002908 Other Accession No.NM_001291746, NM_002908, NM_002908.1, NM_002908.2, NM_002908.3, NM_001291746.1, BC051005, BC117191, BC143885...
Mutations in the NF-κB signaling pathway: implications for human disease. Oncogene 2006; 25: 6831–6843. 11 Grumont RJ, Gerondakis S. The subunit composition of NF-κB complexes changes during B-cell development. Cell Growth Differ 1994; 5: 1321–1331. 12 Liou HC, Sha WC, Scott ML, ...
Oncogene (2013) 32, 5563–5573; doi:10.1038/onc.2013.334; published online 26 August 2013 Keywords: Helicobacter felis infection; NF-kB; MALT lymphoma; gastric cancer INTRODUCTION In many malignancies, changes in the tissue microenvironment, influenced by immune responses, create a niche that ...
B: RNA was isolated from the hearts of adult WT and Nfkb1−/− mice, and mRNA levels of the NF-κB subunits RelA, NF-κB2, c-Rel, and RelB were quantified using qRT-PCR. c-Rel was the only NF-κB subunit to be up-regulated in Nfkb1−/− mice. The RLTD between WT ...
This gene encodes a protein that belongs to the Rel homology domain/immunoglobulin-like fold, plexin, transcription factor (RHD/IPT) family. Members of this family regulate genes involved in apoptosis, inflammation, the immune response, and oncogenic processes. This proto-oncogene plays a role in...
nucleus. Is expressed in axial skeleton; eye; heart; and ureter. Used to study atopic dermatitis. Human ortholog(s) of this gene implicated in breast cancer and immunodeficiency 53. Orthologous to human RELB (RELB proto-oncogene, NF-kB subunit). [provided by Alliance of Genome Resources, ...
Macroautophagy can regulate cell signalling and tumorigenesis via elusive molecular mechanisms. We establish a RAS mutant cancer cell model where the autophagy gene ATG5 is dispensable in A549 cells in vitro, yet promotes tumorigenesis in mice. ATG5 repr