Here we review recent mRNA–protein correlation studies in the light of the quantitative parameters of the gene expression pathway, contextual confounders and buffering mechanisms. Although protein and mRNA levels typically show reasonable correlation, we describe how transcriptomics and proteomics provide ...
Mean Wool Fibre diameter (MFD) is one of the main economic traits of wool. To explore the molecular mechanisms regulating MFD, the expression profiles of different stages of embryonic and adult sheep skin have been investigated through scanning of expressed sequence tags (ESTs) and cDNA microarray...
Distinct gene subsets in pterygia formation and recurrence: dissecting complex biological phenomenon using genome wide expression data Here, we investigated the possible mechanisms of pterygium pathogenesis and recurrence. Methods First we performed a genome wide expression analysis (human ... L Tong,J ...
Biometals in Neurodegenerative Diseases: Mechanisms and Therapeutics is an authoritative and timely resource bringing together the major findings in the fi... AR White,M Aschner,LG Costa,... 被引量: 8发表: 2017年 Getting a GRASP on CASP: properties and role of the cytohesin-associated scaffold...
Ribonucleoprotein (RNP) complexes are critical post-transcriptional regulators of gene expression covering all aspects of RNA activity in eukaryotes such as export, splicing, stability, translation and degradation1,2,3. These RNPs are assemblies of RNA molecules and proteins including RNA-binding proteins...
in various living organisms [9,10,11,12,13,14,15]. With the increasingly accumulated data available on the existence and expression of microproteins in multiple organisms, it will be feasible to unveil the functions and working mechanisms of this family of proteins....
Understanding and studying the molecular mechanisms, through which the GPCRs transduce their signal into the cell, could also be an issue of great importance. There is a strong and accumulated body of evidence indicating that many GPCRs, form hetero-, or homo-dimers in order to transduce their...
When faced with physical and/or microbial aggression, the egg has two major defensive mechanisms--a chemical protection system composed of yolk, albumen and eggshell matrix proteins that provide antimicrobial protection [2, 3, 5, 6], and the intact eggshell that acts as a physical barrier to ...
RNA-binding proteins (RBPs) are essential for the development and function of the immune system. They interact dynamically with RNA to control its biogenesis and turnover by transcription-dependent and transcription-independent mechanisms. In this Review
O. Structure and mechanisms of a protein-based organelle in Escherichia coli. Science 327, 81–84 (2010). Article CAS PubMed Google Scholar Sutter, M., Greber, B., Aussignargues, C. & Kerfeld, C. A. Assembly principles and structure of a 6.5-MDa bacterial microcompartment shell. ...