Dr. David Levin, Professor of Molecular & Cell Biology at Boston University Henry M. Goldman School of Dental Medicine and Professor of Microbiology at Boston University School of Medicine discovered recently a novel, evolutionarily conserved mechanism for the regulation of gene expression. The study ...
Meanwhile, an activated SlWIND1 binds the promoter of the REF1 precursor gene to activate its expression, thereby amplifying REF1 signaling for tissue repair and organ regeneration. The study also found that the application of REF1 has dramatically improved regeneration ability and transformation effic...
"For the first time, we demonstrated that altered function of PRC2 in mouse sperm, before eggs are fertilized, caused epigenetic effects on development and gene expression in the father's offspring," said the study's first author Dr Jessica Stringer. Epigenetic pathways can be disrupted by expo...
A percussion mechanism for a gene gun has a gun body, a percussion assembly and a trigger assembly. The gun body has a trigger chamber, a tubular channel having a valve seat and communicating with the trigger chamber. The percussion assembly is mounted in the tubular channel and has a drive...
weakens DNA binding. Our data provide a molecular basis for the regulation of bacterial sialic acid metabolism. Similar content being viewed by others Bacteria employ lysine acetylation of transcriptional regulators to adapt gene expression to cellular metabolism...
The cDNA corresponding to the gene coding for the 127 amino acids of human transthyretin (TTR) protein was cloned into a pET-M11 vector encoding an N-terminal His6tag and a TEV cleavage site (EMBL Protein and Purification Facility, Germany) and then expressed inE.coliBL21 (DE3) cells (Invi...
gene expression is the gene regulatory network system. What it focuses on is specific interplay among key genes including the effect of the promoter and the enhancer distant from the starting site. It should be pointed out that when we talk about the formalism of gene regulation, the basal ...
Sequence Analysis and Study on the Expression Level of Dmc1 mRNA in Yak and Cattle-Yak Testis offer references for the revealing of the molecular mechanism of infertility of cattle-yak.【Method】RT-PCR was applied to clone the cDNA of Dmc1 gene... LI Xian,LI Qi-Fa,XB Zhao,... - 《S...
In this study, we investigated the molecular mechanism and repertoire of ASC-induced gene expression in human cells. We found that the specific activation of ASC induced AP-1 activity, which was required for optimal IL8 promoter activity. ASC activation also induced STAT3-, but not STAT1-, IFN...
The ancient organism helped offer evidence of regions that are used to regulate gene expression, for the first time, in an invertebrate specie, said Bogdanovic. "It tells us that this mechanism of regulation might have appeared a lot earlier millions of years earlier," he said. "And this tel...