Meanwhile, an activated SlWIND1 binds the promoter of the REF1 precursor gene to activate its expression, thereby amplifying REF1 signaling for tissue repair and organ regeneration. The study also found that the application of REF1 has dramatically improved regeneration ability and transformation effic...
Moreover, the transferred miRNA is functional and could regulate gene expression in neighboring cells. Connexin mutation and gap junctional blockers could eliminate this miRNA intercellular transfer and gene regulation. These data reveal a novel mechanism for intercellular genetic communication. Given that...
Loss of function, whether complete or partial, may be corrected with restoration of gene expression in target cells with DNA or RNA re-expression. Another option for haploinsufficiency disorders is to boost expression of the wild-type allele; for example, by upregulation of a promotor,36 an app...
These mechanisms play a crucial role in gene expression, gene interactions, and the maintenance of genomic stability. In the field of neuroscience, epigenetic mechanisms provide a framework for understanding brain development, aging, cellular diversity, connectivity, and cognitive functions. They are ...
The first report of a gene defect that causes ALS. Article ADS CAS PubMed Google Scholar Gamez, J. et al. Mutational analysis of the Cu/Zn superoxide dismutase gene in a Catalan ALS population: should all sporadic ALS cases also be screened for SOD1? J. Neurol. Sci. 247, 21–28 (...
et al. Tet1 is critical for neuronal activity-regulated gene expression and memory extinction. Neuron 79, 1109–1122 (2013). Article CAS PubMed PubMed Central Google Scholar Kaas, G. A. et al. TET1 controls CNS 5-methylcytosine hydroxylation, active DNA demethylation, gene transcription, and...
1996. CDP/cut is the DNA-binding subunit of histone gene transcription factor HiNF-D: A mechanism for gene regulation at the G1/S phase cell cycle ... AJV Wijnen,MFV Gurp,MCD Ridder - 《Proceedings of the National Academy of Sciences of the United States of America》 被引量: 0发表:...
Our experiments suggest a clear functional role for BDNF in regulation of synaptic strength under these resting conditions, although it must be noted that other genes are also impacted by mIPSC signaling (Figures 1H and 1I). Validating these gene changes and determining the full contributions of ...
Dr. David Levin, Professor of Molecular & Cell Biology at Boston University Henry M. Goldman School of Dental Medicine and Professor of Microbiology at Boston University School of Medicine discovered recently a novel, evolutionarily conserved mechanism for the regulation of gene expression. The study ...
gene expression and gene discovery studies. An experiment with a single DNA chip can provide researchers information on thousands of genes simultaneously. This represents a dramatic increase in throughput such that analysis of genetic data is becoming increasingly practical for more and more human ...