High proteinase 3-anti-neutrophil cytoplasmic antibody (ANCA) level measured by the capture enzyme-linked immunosorbent assay method is associated with decreased patient survival in ANCA-associated vasculitis with renal involvement. J Am SocNephrol. 2003; 14(11): 2926-33....
Thus, mPR3 abundance is a critical disease factor. In addition to direct membrane interaction20,21, we have proposed that high mPR3 levels are achieved by PR3 binding to CD177, a GPI-anchored neutrophil-specific membrane receptor also present in neutrophil granules and released into the ...
Ulcerative Colitis with Positivity for Proteinase 3-Antineutrophil Cytoplasmic Antibody , Yoneda M, Abe J, Kobayashi N, Kubota K, Saito S, Nakajima A: Ulcerative Colitis with Positivity for Proteinase 3-Antineutrophil Cytoplasmic Antibody. ... Keiko Suzuki Satoshi Nakao Akihiro Suzuki Masahiko inamori...
Asp102 and Ser195; using chymotrypsinogen numbering) for proteolytic activity and defined by their active site serine residue [4,12]. PR3 possesses an enlarged binding site with high specificity and differs from NE by
(IP) assays and utilized high-sensitivity mass spectrometry screening. Specifically, we investigated the binding of PRTN3 to potential proteins in HEK293T cells that overexpressed PRTN3 by transfecting an HA-tagged PRTN3 plasmid and subsequently pulldown with the HA antibody. After screening over ...
et al. An antibody against the exosite of the cloned thrombin receptor inhibits experimental arterial thrombosis in the African green monkey. Circulation 91, 2961–2971 (1995). CAS PubMed Google Scholar Kahn, M. L., Nakanishi-Matsui, M., Shapiro, M. J., Ishihara, H. & Coughlin, S. ...
Sweat CPI may be of sweat gland origin because 1) the rate of CPI output in sweat (CPI concentration x sweat rate) is constant over 45 min; 2) antibody against epidermal CPI, which cross-reacts with sweat CPI, localized immunoreactivity in the sweat duct; 3) CPI activity was present in...
Once initiated, therapy will usually be continued for the remainder of the patient's life. Recipients of alpha 1-antitrypsin inhibitor therapy should be immunized against hepatitis B. It is also recommended that this medication not be used in patients with immunoglobulin antibody IgA deficiency that...
Further, it is involved in the treatment of paraffin embedded tissue sections in order to expose antigen binding sites for antibody labeling. Uses Useful for the proteolytic inactivation of nucleases during the isolation of DNA and RNA.Removes endotoxins that bind to cationic proteins such as ...
Proteinase binding and inhibition by the monomeric alpha-macroglobulin rat alpha 1-inhibitor-3. The inhibitory capacity of the alpha-macroglobulins resides in their ability to entrap proteinase molecules and thereby hinder the access of high molecular... JJ Enghild - 《Journal of Biological Chemistry...