Interaction of elicitor-induced DNA-binding proteins with elicitor response elements in the promoters of parsley PR1 genes EMBO J, 15 (1996), pp. 5690-5700 Google Scholar Santner and Estelle, 2010 A. Santner, M Estelle The ubiquitin-proteasome system regulates plant hormone signaling Plant J, 61...
all proteins are fromE. coli. Two methods were used to identify non-interacting proteins, first a set of proteins with no reported interaction signal in Yeast Two-Hybrid Experiments41and secondly complexes whose individual proteins were found in different APMS benchmark...
Over the past 10 years, much research has been dedicated to the understanding of protein interactions. Large-scale experiments to elucidate the global structure of protein interaction networks have been complemented by detailed studies of protein interaction interfaces. Understanding the evolution of interf...
7)合成化学的几个主要分支: multi-component reactions (MCRs), diversity-oriented synthesis (DOS), biology-oriented synthesis (BIOS), and domino(or cascade) reactions 8)PPI早期开发的hot spots鉴定:alanine scanning experiments examine the contributions to the mutual interaction energy between two proteins,...
Although deep learning (DL) models for Protein–Protein Interaction (PPI) prediction have been studied extensively, it has not yet been developed for simulating the natural PPI hierarchy. Here, we suggest HIGH-PPI, a hierarchical graph neural network, for accurate and interpretable PPI prediction. ...
2023, Briefings in Bioinformatics Recent Advances in Deep Learning for Protein-Protein Interaction Analysis: A Comprehensive Review 2023, Molecules Growing ecosystem of deep learning methods for modeling protein-protein interactions 2023, Protein Engineering, Design and Selection©...
to the two kinds of interactions made by a given side chain; interaction made by the residue with a sidechain or main chain atom in the same protein chain and interaction across the protein-protein interface. These two categories of interactions are henceforth referred as “solely inter-protein...
In this Review, we describe the research leading to these breakthroughs and highlight the existence of groups of structurally related PPIs within the PPI target class. For each of these groups, we use examples of successful discovery efforts to illustrate the research strategies that have proved ...
The study of protein-protein interactions is becoming increasingly important for biotechnological and therapeutic reasons. We can define two major areas therein: the structural prediction of protein-protein binding mode, and the identification of the relevant residues for the interaction (so called 'hot...
The protein–domain–residue hierarchy.Two bound proteins and their interacting domains and residues, captured in PDB complex 4IOP. The proteins are a Killer cell lectin-like receptor (in violet) and its partner, a C-type lectin domain protein (in blue). (Left) Interaction as visible from th...