Protein-protein interaction networks (PPI) are one of the vital resources that are available for understanding the processes in a living cell. Protein associations are studied in different perspectives, including biochemistry, quantum chemistry, molecular dynamics, metabolic or genetic/epigenetic networks ...
Evidence construction of Huangkui capsule against chronic glomerulonephritis: A systematic review and network pharmacology YaoDai, ...XiaoMa, inPhytomedicine, 2022 Building protein-protein interaction (PPI) network Aprotein-protein interaction(PPI) network was constructed using a String database (https:/...
A novel link prediction algorithm for protein-protein interaction networks by attributed graph embedding. Computers Biol. Med. 137, 104772 (2021). Article Google Scholar Lv, G., Hu, Z., Bi, Y. & Zhang, S. Learning unknown from correlations: graph neural network for inter-novel-protein in...
“Membrane proximity labeling (proteomics),” which analyzes the interaction of cell membrane proteins, and “intracellular proximity labeling (proteomics)” will be explained in-depth. View chapter Review article Protein and lysate array technologies in cancer research Biotechnology Advances Journal2008, ...
Yet while knowledge of brain PPINs is steadily improving, the complexity and dynamic nature of the heterogeneous central nervous system in normal and disease contexts poses a formidable experimental challenge. In this review, we summarize recent applications of functional proteomics and systems biology ...
A method for measuring the change in heat that occurs when a protein–ligand complex is formed. From these data, the thermodynamic parameters for the interaction can be determined. About this article Cite this article Arkin, M., Wells, J. Small-molecule inhibitors of protein–protein interaction...
reactions8)PPI早期开发的hot spots鉴定:alanine scanning experiments examine the contributions to the mutual interaction energy between two proteins, investigating both the concave and convex PPI regions9)Low success rate for discovering PPI inhibitors was primarily ascribed to: a) the overall characteristic...
Protein–protein interaction in insulin signaling and the molecular mechanisms of insulin resistance J Clin Invest. 1999 Apr;103(7):931-43. Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review A Virkamäki,K Ueki,CR Kahn - 《Journal of Clinical ...
This review provides an overview of the evolution of the study of protein–protein interactions with an emphasis on recent developments in the field that concern the modular architecture of protein–protein interfaces and the networked communications within these binding sites that serve as a driving ...
The featureless interface formed by protein–protein interactions (PPIs) is notorious for being considered a difficult and poorly druggable target. However, recent advances have shown PPIs to be druggable, with the discovery of potent inhibitors and stab