Protein-protein interactions are correlated with a proposed potential of mean force equal to the free energy to desolvate the protein surface that is made inaccessible to the solvent due to the protein-protein interaction. This energy is calculated from the surface free energy of the protein that...
The goal of this study was to relate conformational changes in the N-terminal domain of chicken troponin I (TnI) to Ca 2+ activation of the actin-myosin interaction. The two cysteine residues in this region (Cys48 and Cys64) were labeled with two sulfhydryl-reactive pyrene-...
The interaction of proteins thus prepared was visualized using a single-molecule imaging technique. As a demonstration of this method, a motor protein, kinesin, was labeled with Cy5-puro at an efficiency of about 90%, and the processive movement of kinesin along microtubules was observed by ...
Analysis of predicted interaction networks in context of expression correlation in various conditions reveals the dynamic changes associated with a number of biological processes. Full-size image (31K) View Within Article Figure 1 The performance of machine learning methods on gold standard data using ...
The fusion of X protein and Y protein facilitates the identification of the interaction between X and Y. If X and Y proteins interact, recombination of the fluorescent protein fragments is expected to result in fluorescence emission. (B) The principle of mcBiFC. X protein interacts with Y and...
In the current study, we examined HLHS within the mechanistic framework of the protein–protein interaction (PPI) network or protein ‘interactome’. Proteins fuel the cellular machinery, and their interactions reflect the functions that they subserve. This can be informative of disease mechanisms and...
doi:10.1016/S0891-5245(98)90032-3GwendolynStokesSDOSJournal of Pediatric Health Care
protein interactivitysmall molecule protein interactions and Emil Fisher's enzyme depiction ‐ lock and a key interactiontubulin–colchicine complex ‐ interaction between natural products and proteinsintegrative biology advance ‐ complete genomic and proteomic descriptions of cellprotein–...
protein–protein interactionprotocolquaternary structuresample preparationisotope labelingtoolssubunit arrangementWe recently reported that activation of the highly efficient phospholipase C (PLC) stimulatory m3 muscarinic acetylcholine receptor (mAChR) can induce a long-lasting Gi-mediated heterologous potentiation...
protein interactionsystems biologydiseasedrug discoveryinteractomecomputational predictionCommented the label with id as 'lblAbstractValue' to solve accessibility issue A novel bis-hydroxymethyl-substituted DTTA chelator N ′-Bz-C 4,4′ -(CH 2 OH) 2 -DTTA ( 1 ) and its DTPA analogue C 4,4′ ...