BioinformaticsData miningGene selectionCancerProtein-protein interactionProtein-drug interactionBackground In terms of genomics, bioinformatics conceptualizes biological processes and utilizes computer science to generate knowledge from biological data. Bioinformatics is multidisciplinary in that it merges the ...
Here, we present a proof of concept for a method to study the interaction of different kinds of drugs with protein on a microwell array, to enable the understanding of pharmacokinetics in a fast and facile manner. To this end, we demonstrated the applicability of present method by analysing ...
Current drug development suffers from high cost and low efficiency of the drug discovery process. The therapeutic efficacy of drugs is mediated by physical interaction with their cognate targets (mainly proteins). To monitor protein-drug interactions (PDIs) in vitro is essential for the drug discover...
The study of protein-drug interaction is of pivotal importance to understand the structural features essential for ligand affinity. The explosion of information about protein structures has paved the way to develop structure-based virtual screening approaches. Parasitic protein kinases have been pointed ou...
Because the study of drug interaction with receptor protein is difficult, model systems with serum proteins are utilized. Several of the more important types of bonds or forces of attraction between drug and protein are described, and various examples are presented. 关键词: Animals Rabbits Humans ...
Identifying unexpected drug-protein interactions is crucial for drug repurposing. We develop a comprehensive proteome scale approach that predicts human protein targets and side effects of drugs. For drug-protein interaction prediction, FINDSITEcomb, who
4. General strategies for obtaining protein–protein interaction regulators 5. Perspectives Acknowledgments Author contributions Conflicts of interest ReferencesShow full outline Cited by (10) Figures (7) Show 1 more figure Tables (2) Table 1 Table 2Acta...
GitHub - masashitsubaki/CPI_prediction: This is a code for compound-protein interaction (CPI) prediction based on a graph neural network (GNN) for compounds and a convolutional neural network (CNN) for proteins. DUD-E数据集: DUD-E: A Database of Useful (Docking) Decoys — Enhanced ...
Ghemtio L, Souchet M, Djikeng A, Keminse L, Kelbert P, et al. (2011) HIV- PDI: A Protein Drug Interaction Resource for Structural Analyses of HIV Drug Resistance: 2. Examples of Use and Proof-of-Concept. J Health Med Informat 2:105...
Semi-supervised drug-protein interaction prediction from heterogeneous biological spaces.Background: Predicting drug-protein interactions from heterogeneous biological data sources is a key step for in silico drug discovery. The difficulty of this prediction task lies in the rarity of known drug-protein ...