K., Drug-protein interaction studied by technique of microdialysis combined with high performance liquid chromatography, Rev. Anal. Chem., 1999, 18(6): 383–407.Drug-protein interaction studied by technique of microdialysis combined with high performance liquid chromatography. Zou H F,Wang H L,...
Current drug development suffers from high cost and low efficiency of the drug discovery process. The therapeutic efficacy of drugs is mediated by physical interaction with their cognate targets (mainly proteins). To monitor protein-drug interactions (PDIs) in vitro is essential for the drug discover...
3. Drug discovery by targeting autophagy-related protein–protein interactions 4. General strategies for obtaining protein–protein interaction regulators 5. Perspectives Acknowledgments Author contributions Conflicts of interest ReferencesShow full outline Cited by (10) Figures (7) Show 1 more figure Tabl...
The study of protein-drug interaction is of pivotal importance to understand the structural features essential for ligand affinity. The explosion of information about protein structures has paved the way to develop structure-based virtual screening approaches. Parasitic protein kinases have been pointed ou...
In order for a drug to act upon a receptor or be metabolized by an enzyme it must first be bound to receptor protein or enzyme. Because the study of drug interaction with receptor protein is difficult, model systems with serum proteins are utilized. Several of the more important types of ...
Identifying unexpected drug-protein interactions is crucial for drug repurposing. We develop a comprehensive proteome scale approach that predicts human protein targets and side effects of drugs. For drug-protein interaction prediction, FINDSITEcomb, who
Ghemtio L, Souchet M, Djikeng A, Keminse L, Kelbert P, et al. (2011) HIV- PDI: A Protein Drug Interaction Resource for Structural Analyses of HIV Drug Resistance: 2. Examples of Use and Proof-of-Concept. J Health Med Informat 2:105...
GitHub - masashitsubaki/CPI_prediction: This is a code for compound-protein interaction (CPI) prediction based on a graph neural network (GNN) for compounds and a convolutional neural network (CNN) for proteins. DUD-E数据集: DUD-E: A Database of Useful (Docking) Decoys — Enhanced ...
Protein–drug interactions.Ensemble of machine learning system.Matrix representation of a protein for extracting different descriptors.Position specific sc... L Nanni,A Lumini,S Brahnam - 《Journal of Theoretical Biology》 被引量: 13发表: 2014年 Protein-protein interaction inhibition (2P2I) combining...
The US Food and Drug Administration (FDA) has published a number of guidances that recommend how and when to evaluate these factors during drug development. The most recent FDA draft guidance on drug interactions provides advice for in vitro and in vivo drug interaction studies, including ...