Methyltransferase catalyzes the transfer of methyl to DNA, RNA, proteins and other biomolecules [1]. Methyltransferase-like (METTL) proteins are a seven-chain methyltransferase family with an S-adenosylmethionine binding domain [2]. METTL is a protein encoded by a highly conserved polygenic family an...
Mechanistically, UNC-51-like kinase 1, a core autophagy protein, can phosphorylate the key glycolytic enzyme lactate dehydrogenase A (LDHA) and increase its enzyme activity, then promoting the production of lactate, which drives the Kla of vacuolar protein sorting 34 (Vps34). Vps34 Kla can not...
14. A.k.a. N-terminal kinase-like protein (NTKL), telomerase regulation-associated protein kinase (TAPK), telomerase transcriptional elements-interacting factor (TEIF), and teratoma-associated tyrosine kinase (TRAP). 15. A.k.a. 104-kDa coated vesicle-associated kinase (CVAK104). 16. A.k...
L. et al. YC-1 inhibits HIF-1 expression in prostate cancer cells: contribution of Akt/NF-kappa B signaling to HIF-1 alpha accumulation during hypoxia. Oncogene 26, 3941–3951 (2007). 28. Buckley, D. L. et al. Small-Molecule Inhibitors of the Interaction between the E3 Ligase VHL ...
The plastid-encoded Tic214(YCF1)/YCF2/FtsHi complex emerged early in chlorophyte evolution, too, maybe through the duplication of an early Tic20-like protein (Wunder et al., 2007, Kikuchi et al., 2018). The components of this complex are highly diverse, except for a C-terminal motif, ...
During the movement of ATFS-1 to the nucleus, ubiquitin-like protein 5 (UBL-5) is upregulated with the assistance of ATFS-1 and defective proventriculus homolog protein (DVE-1) [22]. Subsequently, UBL-5 and DVE-1 form a complex that interacts with the promoters of UPRmt-related genes ...
However, in diet-induced obese rats, GSTYc2 subunit, GST8, and GSTP subunits were found to be downregulated [253]. Upregulation of GSTA2 may participate in CA and CS-inhibited adipocyte differentiation [237]. 5.3.3.2 The thioredoxins system and adipocyte differentiation The Trxs system is ...
folding and isolation processes of eEF2 [20]. Furthermore, crystal structure comparisons reveal gross conformational changes in eEF2 upon binding to ribosomes. Within each super-domain grouping, the second super-domain is observed to exhibit a hinge-like motion, which induces a ratchet-like ...
YT521-B homology domain family member 2 (YTHDF2) is an N6-methyladenosine (m6A)-binding protein that was originally found to regulate the stability of mRNA. Growing evidence has shown that YTHDF2 can participate in multifarious bioprocesses, including embryonic development, immune response, and tu...
YC: reviewed, and revised the paper. All authors reviewed the results and approved the final version of the manuscript. Corresponding author Correspondence to Yao Cheng. Ethics declarations Conflict of interest The authors declare that they have no conflicts of interest to report regarding the ...