The methylation modification of m6A has been confirmed to be dynamic and reversible, involving methyltransferase “writers”, demethylase “erasers” and methylated reading protein “readers” [4]. For example, methyltransferase-like 3 (METTL3) and METTL14 can form a steady heterodimer complex. They ...
Mechanistically, UNC-51-like kinase 1, a core autophagy protein, can phosphorylate the key glycolytic enzyme lactate dehydrogenase A (LDHA) and increase its enzyme activity, then promoting the production of lactate, which drives the Kla of vacuolar protein sorting 34 (Vps34). Vps34 Kla can not...
During the movement of ATFS-1 to the nucleus, ubiquitin-like protein 5 (UBL-5) is upregulated with the assistance of ATFS-1 and defective proventriculus homolog protein (DVE-1) [22]. Subsequently, UBL-5 and DVE-1 form a complex that interacts with the promoters of UPRmt-related genes ...
folding and isolation processes of eEF2 [20]. Furthermore, crystal structure comparisons reveal gross conformational changes in eEF2 upon binding to ribosomes. Within each super-domain grouping, the second super-domain is observed to exhibit a hinge-like motion, which induces a ratchet-like rotati...
Methyltransferase-like protein is a ubiquitous enzyme-like protein in the human body, with binding domains for nucleic acids, proteins and other small molecules, and plays an important role in a variety of biological behaviours in normal organisms and diseases, characterised by the presence of a me...
Furthermore, two calcineurin B-like (CBL) proteins were identified as the upstream regulators of CIPK23. In addition, activation of AKT1 by CIPK23 and CBL1 or CBL9 was further confirmed by voltage-clamp recording using a Xenopus oocyte expression system and by patch-clamp recording from root-...
et al. Discovery of a drug-like G-quadruplex binding ligand by high-throughput docking. Chemmedchem 3, 881–884 (2008). 41. Totrov, M. & Abagyan, R. Flexible protein-ligand docking by global energy optimization in internal coordinates. Proteins 215–220 (1997). 42. Lee, K. et al....
International Journal of Molecular Sciences Article Insights into the Mn2+ Binding Site in the Agmatinase-Like Protein (ALP): A Critical Enzyme for the Regulation of Agmatine Levels in Mammals María-Belen Reyes 1, José Martínez-Oyanedel 1,*, Camila Navarrete 1, Erika Mardones 1, Ignacio ...
The plastid-encoded Tic214(YCF1)/YCF2/FtsHi complex emerged early in chlorophyte evolution, too, maybe through the duplication of an early Tic20-like protein (Wunder et al., 2007, Kikuchi et al., 2018). The components of this complex are highly diverse, except for a C-terminal motif, ...
folding and isolation processes of eEF2 [20]. Furthermore, crystal structure comparisons reveal gross conformational changes in eEF2 upon binding to ribosomes. Within each super-domain grouping, the second super-domain is observed to exhibit a hinge-like motion, which induces a ratchet-like ...