10,11 Among them, Ycf2 and five FtsH-like proteins each contain ATPases associated with diverse cellular activities (AAA+) ATPase domain and together form a heterohexameric motor. pdNAD-MDH is a moonlighting protein that is also an enzyme playing a crucial role in conversion of malate to ...
The methylation modification of m6A has been confirmed to be dynamic and reversible, involving methyltransferase “writers”, demethylase “erasers” and methylated reading protein “readers” [4]. For example, methyltransferase-like 3 (METTL3) and METTL14 can form a steady heterodimer complex. They ...
folding and isolation processes of eEF2 [20]. Furthermore, crystal structure comparisons reveal gross conformational changes in eEF2 upon binding to ribosomes. Within each super-domain grouping, the second super-domain is observed to exhibit a hinge-like motion, which induces a ratchet-like rotati...
For these reasons, both TNBC and basal-like breast cancers usually lead to an aggressive disease, with a high probability of metastasis [50], and with poor prognosis, which is due, in part, to the absence of an existing effective targeted therapy. 2.2. Altered Protein Kinases in Breast ...
folding and isolation processes of eEF2 [20]. Furthermore, crystal structure comparisons reveal gross conformational changes in eEF2 upon binding to ribosomes. Within each super-domain grouping, the second super-domain is observed to exhibit a hinge-like motion, which induces a ratchet-like ...
Acknowledgements The authors would like to thank Drs Eva Heinz, Trevor Lithgow, Ana Traven, Victoria Hewitt, Takuya Shiota, Ian Collinson, Jacek Jaworski, Katarzyna Chojnacka for experimental help, discussions and materials. This work was supported by Ministerial Ideas Plus schema 000263, National ...
et al. Discovery of a drug-like G-quadruplex binding ligand by high-throughput docking. Chemmedchem 3, 881–884 (2008). 41. Totrov, M. & Abagyan, R. Flexible protein-ligand docking by global energy optimization in internal coordinates. Proteins 215–220 (1997). 42. Lee, K. et al....
These catalytic differences are in part a consequence of the unusual active site motif of DsbP (CAVC); substitution to the EcDsbC-like (CGYC) motif converts the catalytic properties to those of EcDsbC. Structural comparison of the 12 independent subunit structures of DsbP that we determined ...
Chromodomain Y-like protein CPT1A: Carnitine palmitoyltransferase 1A CRC: Colorectal carcinomas CS: Citrate synthase DCA: Dichloroacetate DPF: Double PHD finger DPF2: Also known as BAF45d DSB: Double-strand break ENO1: Enolase 1 ESCC: Oesophageal squamous cell cancer ...
binding immunoglobulin-like lectins (siglecs) expressed by immune cells to produce signals that negatively regulate the immune system [111]. Similar to the immune checkpoint receptor programmed cell death 1 (PD-1), most siglecs contain a cytosolic immunoreceptor tyrosine-based inhibitory motif (ITIM)...