Protein-tyrosine phosphatase PCP-2 inhibits beta-catenin signaling and increases E-cadherin-dependent cell adhesion. J Biol Chem 2006; 281: 15423-15433.Yan HX, Yang W, Zhang R, Chen L, Tang L, Zhai B, Liu SQ, Cao HF, Man XB, Wu HP, Wu MC, Wang HY (2006) Protein-tyrosine ...
having one of the following formulae (II) to (IV), wherein R′ is H or C-Calkyl; or an enol tautomer of a compound of formula (I) in which any of the groups R or R′ is hydrogen; in the manufacture of a medicament for use as a protein tyrosine phosphatase (PTP) inhibitor. ...
Mutation in the drug target site still decreases the efficacy of irreversible inhibitors. Osimertinib, a third-generation EGFR covalent inhibitor, binds to the C797 residue in the ATP-binding site of EGFR and potently inhibits receptor activation, which can be applied to positive T790M EGFR. The ...
protein tyrosine phosphatasesSHP2 inhibitorsThe front cover picture shows the first nanomolar and specific inhibitor of the protein tyrosine phosphatase SHP2 depicted in the protein binding site. The molecule contains benzene sulfonate as a phosphotyrosine mimicking fragment, binding affinity and selectivity...
02 December 2015 Discovery of a Novel Inhibitor of the Protein Tyrosine Phosphatase Shp2 Chuan Chen*, Mengmeng Cao*, Siyu Zhu, Cuicui Wang, Fan Liang, Leilei Yan & Duqiang Luo Shp2 is a ubiquitously expressed protein tyrosine phosphatase (PTP) related to adult acute myelogenou...
英文别名: PTPN2 (Tyrosine-protein Phosphatase Non-receptor Type 2, T-cell Protein-tyrosine Phosphatase, PTN2, PTPT, TCPTP, TC-PTP, T-Cell PTP) (Biotin)中文名: 中文别名: CBNumber: CB04965822 分子式: 分子量: 0 MOL File: Mol file ...
Shp2, a protein-tyrosine phosphatase encoded by Ptpn11, promotes activation of Ras-Erk and PI3K-Akt and is crucial for hematopoietic cell function; however, no studies have examined Shp2 function in particulate-stimulated ROS production. Maximal Dectin-1-stimulated ROS production corresponded ...
英文别名: Lymphoid-specific Protein Tyrosine Phosphatase Isoform 2 (PTPN22)中文名: 中文别名: CBNumber: CB4983266 分子式: 分子量: 0 MOL File: Mol file 化学性质 安全信息 用途 供应商 2 Lymphoid-specific Protein Tyrosine Phosphatase Isoform 2 (PTPN22) 化学性质...
产品名称:Protein Tyrosine Phosphatase, Non Receptor Type 13 (PTPN13) Polyclonal Antibody 产品型号:CAU23254 产品展商:Biomatik 产品文档:无相关文档 简单介绍 Protein Tyrosine Phosphatase, Non Receptor Type 13 (PTPN13) PolyclonalAntibody Protein Tyrosine Phosphatase, Non Receptor Type 13 (PTPN13) Polyclonal...
4) tyrosine kinase inhibitor 酪氨酸蛋白激酶抑制剂 1. Objective To assess the effect of tyrosine kinase inhibitor (2,5-MC) on the inhibition of in-stent inti-mal hyperplasia. 目的评估酪氨酸蛋白激酶抑制剂2,5-MC抑制支架植入术后内膜增殖的效果。 更多例句>> 5) Protein tyrosine kinase inhibitor...