Specific inhibitors of protein phosphatase 2A (PP2A) mediate anticancer effects by augmenting the tumor-killing activity of natural killer (NK) cells. In this study, new PP2A inhibitors, aminocytostatins A鈥揈, were isolated from Kitasatospora sp. MJ654-NF4 and structurally characterized. Amino...
PROTEIN PHOSPHATASE 2A INHIBITORS TO INHIBIT HOST-CELL MEDIATED VIRAL REPLICATIONMARKOVITZ, David, MNeil FAULKNERBrian LANE
protein tyrosine phosphatase inhibitorsabrogate all such effects of cAMP. Those investigators then postulated that cAMP may regulate the paxillin phosphorylation state by eliciting an increase in tyrosine phosphatase activity rather than by an inhibitory action on tyrosine kinases. Later studies showed the ...
including cell growth, proliferation and cell polarity1,2,3,4,5. Protein phosphatase 2A (PP2A) is one of the major evolutionarily conserved serine/threonine phosphatases in eukaryotes
Cancerous inhibitor of protein phosphatase 2A (CIP2A) is overexpressed in most human cancers and has been described as being involved in the progression of several human malignancies via the inhibition of protein phosphatase 2A (PP2A) activity toward c-Myc. However, with the exception of this ...
Cytoskeletal reorganization of human platelets induced by the protein phosphatase 1/2 A inhibitors okadaic acid and calyculin A. Okadaic acid (OA) and calyculin A (CLA), which are potent and specific inhibitors of serine/threonine protein phosphatases type 1 and 2A, have been shown t... Y Yan...
No significant chloroplast protein phosphatase activity was detected using these exogenous phosphoproteins. The dephosphorylation of endogenous thylakoid light-harvesting chlorophyll a/b binding proteins in situ was inhibited by fluoride, but not by microcystin-LR or okadaic acid, diagnostic inhibitors of ...
Protein Phosphatase 1 (PP1) is a major serine/threonine phosphatase in eukaryotes, participating in several cellular processes and metabolic pathways. Due to their low substrate specificity, PP1’s catalytic subunits do not exist as free entities but ins
Inhibitors、抑制剂 Insulin-Like Growth Factors (IGF)、胰岛素样生长因子 Integrins、整合素家族 Interleukins and Related Peptides、白细胞介素及相关肽 Intermedins、中叶激素 Ion Channels、离子通道 Kassinins肽 Keratinocyte Growth Factor(KGF)、角质细胞生长因子 Kinases/Phosphatase Substrates、激酶/磷酸酶底物 Kine...
Interestingly, protein phosphatase 2 (PP2A) is a serine/threonine phosphatase and negatively regulates several signaling pathways. Previously it was shown that the expression levels of cellular inhibitors of PP2A (CIP2A) and novel splice variants of CIP2A are associated with sensitivity to imatinib in...