The dataset of human proteins interacting with SARS-CoV-2 proteins, was compiled using the COVID-19 UniProtKB resource (61;https://covid-19.uniprot.org/uniprotkb?query=*) and IntAct database (20;https://www.ebi.ac.uk/intact/home). IntAct provides a COVID-19 dataset of SARS-CoV-2: h...
Identifying protein interfaces can inform how proteins interact with their binding partners, uncover the regulatory mechanisms that control biological functions and guide the development of novel therapeutic agents. A variety of computational approaches have been developed for predicting a protein’s interfaci...
Leishmania has 195 eukaryotic protein kinases (ePKs) divided into six groups, classified according to catalytic domain conservation (CMGC, AGC, CAMK, STE, NEK, CK1), and an additional group here classified as ‘Others’, which contains diverse important eukaryotic cell signal transduction functions ...
The transcription units (TUs) of a gene circuit include three biological elements: the promoter, the coding sequence (CDS), and the terminator. The functions of TUs are represented by substances encoded in CDSs, and the initiation and regulation of CDSs occur at the promoter level. Therefore, ...
and two feature normalization algorithms) and providing nine types of interactive plots for statistical features visualization (including histogram, kernel density plot, heatmap, boxplot, line chart, scatter plot, circular plot, protein three dimensional structure plot and ligand structure plot).iFeature...
The locations and functions of C4 proteins are more varied but importantly include GTPases and secretory pathway proteins. Small GTPases are associated with intracellular vesicular trafficking and regulate a variety of membrane fusion events [70,71]. C5, C6 and C7 proteins are mostly cytosolic or...
(a) Bar chart showing the numbers of interactions being specific and non-specific to the cancer types and their count ratio in the 12 different cancer types. (b) Graph indicates the prevalence of dPPIs in different cancers. (c) Topological characteristics of differential interactome networks. ...
which may indicate that there are three essential components or protein functions in GIs. Moreover, the analysis showed that most GIs exist in rod shape species and this may indicate a possible relation between the HGT and the rod shape A possible factor could be the surface area to volume ...
Accurate interaction networks (interactomes) are fundamental to answering questions about how the biochemical machinery of cells organizes matter, processes information, and carries out transformations to perform specific functions leading to various phenotypes. Toward this goal, a number of experimental[1]...
2 2 for each dataset. the probability density functions learned from the biogrid data and dip data are shown in figure 3 (a) and (b) respectively. as shown in figure 3 , the two estimated distributions for each dataset are well separated. as stable interactions tend to be encoded by ...