(e.g., DNA and RNA) to perform their functions. Thus, the study of proteins’ interactions is crucial to understand their role inside the cell. Since this type of interactions can be of several types, the termprotein-protein interactionrefers to a variety of events happening inside the cell...
(3D) structure of protein complexes and protein-protein interfaces. A single protein can be involved in variety of protein complexes. Same complex can perform different functions depending on several factors such as, stage of cell cycle, the nutritional status of the cell, the cellular compartment...
(a) Bar chart showing the numbers of interactions being specific and non-specific to the cancer types and their count ratio in the 12 different cancer types. (b) Graph indicates the prevalence of dPPIs in different cancers. (c) Topological characteristics of differential interactome networks. ...
The number of the phylum’s species in each pattern. The bubble chart illustrates the resulting patterns in more detail, where there are all the patterns in the x-axis and the phylum names in the y-axis. A bubble for a patternPand phylumPhyrepresents the number of species that belong to ...
Their expression is dynamically regulated and shows spatiotemporal patterns among cell types, tissues and developmental stages. CircRNAs have important biological functions in many physiological processes, and their aberrant expression is implicated in many human diseases. Due to their high stability, ...
The locations and functions of C4 proteins are more varied but importantly include GTPases and secretory pathway proteins. Small GTPases are associated with intracellular vesicular trafficking and regulate a variety of membrane fusion events [70,71]. C5, C6 and C7 proteins are mostly cytosolic or...
Proteins dynamically interact with each other to perform their biological functions. The dynamic operations of protein interaction networks (PPI) are also reflected in the dynamic formations of protein complexes. Existing protein complex detection algori
which can be generated by chlorinated polyamines4as well as bis-γ-glutamyl polyamine andɛ(γ-glutamyl)lysine cross-links formed by TGase reaction29,30(Figures 4a andb). The four types of cross-links formed between specific residues of the NET proteins could be found (Figures 4a and b)...
It is assumed that binding interfaces, too, are conserved evolutionary modules that are reused between proteins of different functions and retained during evolution [2, 3]. Therefore, domain–domain interactions are often regarded as the currency of protein–protein interactions. Based on this ...
In highly multiplexed image datasets, each pixel is represented as a multiplexed pixel profile: a one-dimensional vector containing the intensity of each marker at that spatial location. We developed CAMPA to identify consistent types of pixel profiles across different experimental conditions, even when...