Chapter 1From Sequence to Structure: Covers the basics of protein sequence and structure, from amino acids to protein architecture and domains.Chapter 2From Structure to Function: Explains the types of reactions various proteins participate in and the functions they perform.Chapter 3Control of Protein...
These archaea are polyphyletic and occupy specific ecological niches. Notably, similar to how a semantic meaning of a word exists on a spectrum and a word can have multiple semantically appropriate meanings in a context (Fig. 2C), the MCR complex can confer different functions depending on the...
the protein and readout modules generate the predicted translation, rotation, and dihedral updates for the current state. Further details about the model are given in “Transformation of the protein conformation”
folding, and structural maturation of almost one-third of the cellular proteome. It houses several resident proteins for these functions including the 21 members of the protein disulfide isomerase (PDI) family. The signature of proteins belonging to this family is the presence of the thioredoxin...
Function.Integration host factor (IHF) is a small heterodimeric protein that specifically binds to DNA and functions as an architectural factor in many cellular processes in prokaryotes. Structure.The protein is a heterodimer of two related subunits each made of three helices and a two-stranded ß...
[106,107] and directly interacts with a variety of proteins, showing different functions depending on the context of cell types [108,109]. Menin is critical for MLL1 to regulate its target genes [110,111,112]. Menin is also required for MLL1-r leukemia, as conditional knockout of Men...
ProtCAD ProtCAD is a suite of tools for the design and engineering of novel protein structures, sequences, and functions. It allows users to build and manipulate complex protein structures, generate and evaluate sequence libraries, and simulate mutational effects. ProtCAD is a suite of tools for...
We supplied four different types of MSAs to AF2: (1) the MSAs generated by using the default AF2 settings, (2) the top paired MSAs constructed using HHblits, described above, (3) both alignments together and finally, (4) the top paired and single-chain MSAs from HHblits to speed up pre...
POGLUT1, this systematic review focuses on structural domains and dual function of POGLUT1 along with all possible pathways experimentally observed in specific cell types. It also covers a wide range of literature along with suggestions to highlight the causative role of POGLUTs in human diseases...
The functional distance measure of Yu et al., which the authors refer to as the "total ancestry measure for GO," has the obvious advantage that it considers all known functions of a pair of proteins, allowing for a great degree of precision in assessing functional similarity. Moreover, unlik...