Human U3 protein14a is a novel type ubiquitin ligase that binds RB and promotes RB degradation depending on a leucine-rich region. Biochim Biophys Acta Mol Cell Res. 2018;1865:1611–20. Article CAS PubMed Google Scholar Hu Q, Ye Y, Chan LC, Li Y, Liang K, Lin A, et al. ...
别名:ARHGAP24; Filamin A associated RhoGAP; FILGAP; p73; p73RhoGAP; RAC1 and CDC4 specific GTPase activating protein of 72kDa; RCGAP72; Rho GTPase activating protein 24; Rho type GTPase activating protein 24; Rho GTPase-activating protein 24; RhoGAP of 73 kDa; Sarcoma antigen NY SAR 88;...
81 In addition, conjugation of poly-M6Pn with anti-PD-L1 antibody led to a significant decrease of PD-L1 at the cell surface.81 Whereas the expression of CI-MPR is ubiquitous, the expression of certain LTRs is tissue specific. Molecules that target tissue-specific LTRs could induce the ...
System-wide approaches have unveiled an unexpected breadth of the RNA-bound proteomes of cultured cells. Corresponding information regarding RNA-binding proteins (RBPs) of mammalian organs is still missing, largely due to technical challenges. Here, we d
Thus, plant viruses containing protein macromolecules are often very effective in stimulating specific antibody production. The subunits of a viral protein coat are much less efficient. It is specific regions on antigens, termed epitopes, that induce and interact with specific antibodies. Epitopes can...
The factors that can activate MAPK pathways, such as environmental stresses and growth factor stimulation, can also activate MKP pathways (Boutros et al., 2008; Patterson et al., 2009), supporting the notion that there is a tight and specific control of MAPK activation by MKP activation. In...
These findings indicate that the stage-dependent and androgen-specific regulation of uterine AR protein abundance is associated with changes in endometrial functional gene expression. Flutamide reversed metabolic and endocrine abnormalities and partially restored fertility in DHT + INS-exposed pregnant ...
Peritoneal metastasis, which accounts for 85% of all epithelial ovarian carcinoma (EOC) metastases, is a multistep process that requires the establishment of adhesive interactions between cancer cells and the peritoneal membrane. Interrelations between E
Ischemic stroke is highly concerning because it often leads to severe long-term neurological disability. Among clinical trials, ischemic stroke and inflammatory bowel disease interactions have been increasingly reported in recent years. Therefore, using
The transactivation activity of c-Rel is considerably weaker than that of RelA. RelA, p50, and c-Rel are the major components of NF-κB complexes, binding to most of the known cis-acting κB sites. Each κB site preferentially binds a specific set of NF-κB complexes as de...