Another example is Sterol regulatory element-binding protein 1 (SREBP1/SREBF), which abnormally activates lipogenesis to high levels in cancer cells and promotes growth. SREBP1 is specifically di-methylated at R321 by protein methyl arginine transferase 5 (PRMT5), thus stabilizing SREBP1 via a re...
For MT staining, after deparaffinization with xylene, the sections were treated with Bouin’s solution at 56 °C for 30 min and washed under running tap water until the sections were clear. The sections were subsequently stained with Weigert’s hematoxylin (A:B = 1:1), followed by staining...
The first generation of recombinant proteins included proteins with native structures, while the second generation involved proteins with improved properties, especially PK, biodistribution, specificity, efficacy, and minimal side effects. The third generation will include recombinant proteins that have been ...
别名P115-RhoGEF General vesicular transport factor; General vesicular transport factor p115; P115; TAP; Transcytosis associated protein; VDP; Vesicle docking protein; USO1_HUMAN. 说明书100ul 200ul 研究领域**学 信号转导 结合蛋白 G蛋白偶联受体 ...
In Supplementary Figure 1, 13 peptides unique to rat TRPA1 were identified by MS analysis, demonstrating specificity of the Neuromics antibody used for immunoprecipitation and Western blot identification. Co-immunoprecipitation, Orthophsphate Labeling and Western Blotting For co-immunoprecipitation, TG cult...
This suggested that the predominant antibody response was most probably not targeted against any linear epitopes. Figure 6 Antigenic specificity of immune sera. Analysis of Day 56 antiserum from individual rabbits immunized with HPV-11 L1 NLS- plant protein extract. Sera were tested against equal ...
In eight of 10 consecutive cases of IgM monoclonal gammopathy of undetermined significance (MGUS), the M-protein had specificity towards various tissues as... V J?Nsson,HD Schr?Der,TS Jensen,... - 《Journal of Internal Medicine》 被引量: 3发表: 2010年 Monoclonal gammopathy‐associated periphe...
The MUC1 TR-derived peptide used as a part of the model LTBMUC1 protein has seven potential O-glycosylation sites predicted in silico by NetOGlyc (Ser-131, Thr-132, Thr-140, Ser-141, Thr-145, Ser-151, and Thr-152), but only serine and threonine in GSTAP motif (Ser-131, Thr-132...
The stress resistance of the weak tpk3 probably does not arise due to any Tpk-isoform specificity as the residual Tpk activity in the weak tpk3 mutant is thought to be higher than that in the weak tpk1 and tpk2 mutants and, for example, growth defects including slow growth are more ...
SMNDC1 is a Tudor domain protein that recognizes di-methylated arginines and controls gene expression as an essential splicing factor. Here, we study the specific contributions of the SMNDC1 Tudor domain to protein-protein interactions, subcellular localization, and molecular function. To perturb the...