Protein Synthesis Inhibitor is a substance that interferes with the process of protein synthesis by blocking the translation of mRNA into proteins within a cell. AI generated definition based on: xPharm: The Comprehensive Pharmacology Reference, 2007 ...
we excluded puromycin and observed little background signal. Inclusion of puromycin resulted in robust levels of translation. However, introduction of either homoharringtonine, an inhibitor of elongation, or the Poly(A) SPOT-ON reduced nascent protein synthesis by 77.6% and 70.4%, respectively (F4,...
molecular docking revealed the low-energy binding conformations of NLE and its potential target RIOK2. In conclusion, NLE is a protein synthesis inhibitor with anticancer activity.
Discovery of a natural product-like iNOS inhibitor by molecular docking with potential neuroprotective effects in vivo. PLoS One. 2014;9(4):e92905. PubMed PubMed Central Google Scholar Tejo C, See YFA, Mathiew M, Chan PW. Synthesis of 1, 4-amino alcohols by Grignard reagent addition to...
Design strategies based on the peptide epitope are also logical, since the native ligand is close to the size of a drug-sized inhibitor. Such epitope-mimetic design was recently demonstrated for the HIF1α/the von Hippel-Lindau protein (VHL) interaction (Buckley et al., 2012a, Buckley et ...
The synthesis of 3-deoxy-L-fucose (3,6-dideoxy-L-xylo-hexose) (2009) A general methodology toward drug/dye incorporated living 179 copolymer-protein hybrids: (NIRF dye-glucose) copolymer-avidin/BSA conjugates as 180 ... Thisbe,K.,Lindhorst,... - 《Liebigs Annalen Der Chemie》 被引量: ...
7e). These results suggest that OTULIN stabilized GPX4 independently of protein synthesis. To determine whether OTULIN affects GPX4 stability associated with proteasomal degradation, osteosarcoma cells were treated with proteasome inhibitors (MG132 and PS341) and a lysosomal inhibitor (E64D) to prevent ...
mTOR regulates cell growth, proliferation, protein synthesis, and transcription48,49,50,51,52,53,54. ROCK inhibitors are already used as antitumor drugs in patients, while mTOR inhibitors are used to prevent transplant rejection, promote longevity, and treat cancer in clinical trials. Thus, ...
inhibition of glycolysis may restore drug resistance.275Higher lactate concentrations are also accompanied by upregulation of carbonic anhydrase 1 (CA1) and α-synuclein (α-Syn) in some cell lines.274Some studies suggest that CA1 may be involved in fatty acid de novo synthesis,281while α-Syn...
Synthesis and chemical structures of CID755673 and CID797718. CID755673, a compound identified and confirmed as a PKD1 inhibitor after interrogation of the PMLSC library, and CID797718, an analog of CID755673 obtained during the synthesis of the latter structure, were synthesized as described in ...