DISTORTION OF FIDELITY#INHIBITORS OF AMINOACYL-tRNA BINDING#INHIBITORS OF PEPTIDYL TRANSFER#INHIBITORS OF THE EXIT TUNNEL — THE MACROLIDES#INHIBITORS OF TRANSLOCATION#INHIBITORS OF TRANSLATION FACTORSStructural Aspects of Protein Synthesisdoi:10.1142/9789812565785_0010Anders LiljasLund University, Sweden...
In this lesson we'll first review the basic steps of building new proteins through protein synthesis. Then we'll look at two main ways that...
3.2Local protein synthesis Given that the maintenance of increased synaptic strength in late-phaseLTPrequiresprotein synthesis[84], it is conceivable that structural plasticity also depends on protein synthesis. Theprotein synthesis inhibitoranisomycin inhibits the synapse-specific spine enlargement induced by...
Antibiotic Action on DNA and Protein Synthesis Antibiotics are substances produced by microorganisms, which have the property of inhibiting the growth of other microorganisms. Many of them exert their action by interfering with a particular stage in the synthesis of nucleic acids and proteins. They ar...
Many antibiotics, including the macrolides, inhibit protein synthesis by binding to ribosomes. Only some of the macrolides affect the peptidyl transferase ... SM Poulsen,C Kofoed,B Vester - 《Journal of Molecular Biology》 被引量: 321发表: 2000年 In vitro and in vivo evaluation of C-20- an...
6-fluorotryptophan; methyltryptophan; fusidic acid; kasugamycin; 7-methylguanosine 5′-phosphate; w-methyllysine; O-methylthreonine; norleucine; pactamycin; puromycin (a potent inhibitor of prokaryotic and eukaryotic protein synthesis); selenomethionine; sparsomycin; streptomycin; tetracycline antibiotics; ...
The worldwide emergence of antibiotic resistance poses a serious threat to human health. A molecular understanding of resistance strategies employed by bacteria is obligatory to generate less-susceptible antibiotics. Albicidin is a highly potent antibact
potential solution presented in this work, of combining CPPs with an antibiotic protein synthesis inhibitor (NAF-144–67 + CHX; Figs.5–7), could represent a viable combination therapy that enhances the efficacy of CPPs towards metastatic cancers (Fig.8). In addition to protein synthesis ...
and glutamine metabolism in tumor cells are also reprogrammed. The intermediates of these pathways can enter the tricarboxylic acid cycle to assist lipid and protein synthesis and promote cell survival, and some antioxidant substances, such as GSH and NADPH, produced midway can also reduce ROS levels...
2). The fluorescent peak from untreated Vero-d2EGFP cells shifted to uniform peaks at progressively lower intensities after 4 h and 8 h incubations with cycloheximide, a protein synthesis inhibitor (Fig. 2a). Quantification of the remaining signals with both a plate reader and cyto...