Inhibition of protein synthesis in reticulocytes by antibiotics. I. Effects on polysomes. Biochim. Biophys. Acta. 119:109.Baglioni C.Inhibition of protein synthesis in reticulocytes by antibiotics:III. Mechanism of action of sparsomycin. Biochimca et Biophysica Acta-Nucleic Acids and Protein ...
The streptogramins and related antibiotics (the lincosamides and macrolides) (MLS) are important inhibitors of bacterial protein synthesis. The key reaction in this process is the formation of a peptide bond between the growing peptide chain (peptidyl-tRNA) linked to the P-site of the 50S rib...
When another, untreated, population of cells was added to the muconomycin- treated cells, protein synthesis was not inhibited in the untreated population; action of the drug was thus shown to be confined to the treated cells. In melanoma cells treated with neuraminidase and muconomycin, ...
Molecular basis for carrier protein-dependent amide bond formation in the biosynthesis of lincosamide antibiotics Article Open access 12 June 2023 Introduction The increased incidence and dissemination of microbial resistance to antimicrobials, the lack of incentive for development of these drugs in the ...
Inhibition of protein synthesis in reticulocytes by antibiotics: IV. Ribosome behaviour after puromycin release of growing peptide chains Puromycin causes release of growing polypeptide chains from ribosomes. Polyribosomes are not degraded during a short incubation with puromycin, but are deg... JLC ...
et al. Inhibition of an HIV-1 Tat-derived peptide binding to TAR RNA by aminoglycoside antibiotics. Bioorg. Med. Chem. Lett. 5, 2755–2760 (1995). Article CAS Google Scholar Mei, H.-Y. et al. Inhibitors of protein–RNA complexation that target the RNA: specific recognition of ...
The protein levels of class I, class IIa, class IIb, and class IV HDAC isoenzymes were significantly elevated both in human atherosclerotic tissue samples and in atherosclerotic aorta of ApoE−/− mice. Treatment of ApoE−/− mice with SAHA reduced significantly the extent of ...
In comparison to their planktonic forms, they are phenotypically different mainly in the expression of genes and growth rates [2]. Biofilms portray a protected form of growth, which make bacterial cells 1000-fold more resistant to antibiotics and the immune system of the host than the planktonic...
a heme protein secreted by leukocytes, is one of the most studied and plays a key role in cellular inflammation and oxidative stress [46,47,48]. Through the generation of microbicidal reactive oxidants, MPO has become increasingly recognized as an essential component of the innate immune system ...
Protein - Enzymes, Inhibition, Regulation: Some molecules very similar to the substrate for an enzyme may be bound to the active site but be unable to react. Such molecules cover the active site and thus prevent the binding of the actual substrate to the