Protein half-life The time required for the amount or concentration of a protein to be reduced by 50% under physiological conditions. It is a measure of the propensity of a protein to be degraded by the ubiquitin–proteasome system (UPS). Proteins with short half-lives are rapidly degraded ...
Life - DNA, RNA, Protein: The specific carrier of the genetic information in all organisms is the nucleic acid known as DNA, short for deoxyribonucleic acid. DNA is a double helix, two molecular coils wrapped around each other and chemically bound one to
Proteins are essential molecular building blocks of life, responsible for most biological functions as a result of their specific molecular interactions. However, predicting their binding interfaces remains a challenge. In this study, we pres
The half-life of retinol-binding protein is about 10 hours and, as with serum prealbumin, it has a small body pool and is a more specific marker of subtle changes in protein stores. Similar to serum albumin and serum prealbumin, retinol-binding protein levels decrease during inflammatory ...
(often an IgG subclass) at the fragment crystallizable (Fc) region. Conjugation to IgG provides several benefits to therapeutics, including increased serum half-life (through increased size and, consequently, reduced clearance) and recycling (through increased interaction with the neonatalFc receptor, ...
AI-Driven Efficient De Novo design of GLP-1RAs with Extended Half-Life and Enhanced Efficacy Ting Wei, Xiaochen Cui, Jiahui Lin, Zhuoqi Zheng, Taiying Cui, Liu Cheng, Xiaoqian Lin, Junjie Zhu, Xuyang Ran, Xiaohun Hong, Zhangsheng Yu, Haifeng Chen bioRxiv 2025.03.26.645438 • ProteinMPN...
up to 120 days and stable albumin adducts a half-life of 20–25 days (reviewed in Sabbioni and Jones2002; Skipper and Tannenbaum1990; Törnqvist et al.2002)) in humans. Reaction products with hemoglobin accumulate up to 60 times a single daily dose and albumin adducts up to 29 times a...
Carbonic anhydrases have evolved multiple times and, therefore, are an example of convergent evolution of catalytic function. Their metabolic significance is emphasized by the fact that they are found in all domains of life [88, 90–92]. We performed phylogenetic analyses for CAH1 as discussed ...
we examined whether LCRs occur randomly within protein sequences. We located the centre positions of LCRs on a continuous scale ranging from the centre to the extremities of the protein sequence by recording their normalised centre positions and folding the resulting distribution in half. We compared...
[36] also employed RF and SVM classifiers, but their method uses more than 100 different features of mRNA and proteins, extracted from the literature or computed from the protein and RNA sequences to make predictions. Examples of such features include mRNA half-life, predicted protein secondary ...